Effects of Chitosan Derivative N-[(2-Hydroxy-3-Trimethylammonium)Propyl]Chloride on Anticoagulant Activity of Guinea Pig Plasma

被引：0
|
作者：
N. N. Drozd
B. Ts. Shagdarova
A. V. Il’ina
V. P. Varlamov
机构：
[1] Ministry of Health of the Russian Federation,National Research Center for Hematology
[2] Russian Academy of Sciences,Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”
来源：
Bulletin of Experimental Biology and Medicine | 2017年 / 163卷
关键词：
quarternized chitosan derivative; anticoagulant activity; heparin; protamine sulfate; guinea pigs;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 70 aIIa U/kg non-fractionated heparin shortened plasma clotting time (shown by partial activated thromboplastin time, thrombin time, and prothrombin time). Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 1 mg/kg (100 aXa U/kg) low-molecular-weight heparin (clexane) led to shortening of plasma clotting time in the ReaClot Heparin test and to prolongation of plasma amidolytic activity in the factor Xa chromogenic substrate test.
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页码：340 / 343
页数：3
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