Diallyl disulfide attenuates acetaminophen-induced renal injury in rats

被引：7

作者：

Shin J.-Y. ^{[1
,2
]}

Han J.-H. ^{[2
]}

Ko J.-W. ^{[2
]}

Park S.-H. ^{[2
]}

Shin N.-R. ^{[2
]}

Jung T.-Y. ^{[2
]}

Kim H.-A. ^{[2
]}

Kim S.-H. ^{[3
]}

Shin I.-S. ^{[2
]}

Kim J.-C. ^{[2
]}

机构：

[1] Ministry of Food and Drug Safety, Cheongju

[2] College of Veterinary Medicine, Chonnam National University, Gwangju

[3] Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, Jeongeup

来源：

Laboratory Animal Research | 2016年 / 32卷 / 4期

关键词：

Acetaminophen; diallyl disulfide; KIM-1; NCAL; nephrotoxicity; protective effect;

D O I：

10.5625/lar.2016.32.4.200

中图分类号：

学科分类号：

摘要：

This study investigated the protective effects of diallyl disulfide (DADS) against acetaminophen (AAP)-induced acute renal injury in male rats. We also investigated the effects of DADS on kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NCAL), which are novel biomarkers of nephrotoxicity in renal tissues, in response to AAP treatment. The following four experimental groups were evaluated: (1) vehicle control, (2) AAP (1,000 mg/kg), (3) AAP&DADS, and (4) DADS (50 mg/kg/day). AAP treatment caused acute kidney injury evidenced by increased serum blood urea nitrogen (BUN) levels and histopathological alterations. Additionally, Western blot and immunohistochemistry analysis showed increased expression of KIM-1 and NCAL proteins in renal tissues of AAP-treated rats. In contrast, DADS pretreatment significantly attenuated the AAP-induced nephrotoxic effects, including serum BUN level and expression of KIM-1 and NCAL proteins. Histopathological studies confirmed the renoprotective effect of DADS. The results suggest that DADS prevents AAP-induced acute nephrotoxicity, and that KIM-1 and NCAL may be useful biomarkers for the detection and monitoring of acute kidney injury associated with AAP exposure. © 2016, BioMed Central Ltd.

引用

页码：200 / 207

页数：7

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