Genotypic analysis and latent membrane protein 1 expression of Epstein-Barr virus in extranodal NK/T-cell lymphoma from Northern Chinese patients

被引：0
作者：
Haijuan Wang
Hui Li
Xiaoming Xing
Chengquan Zhao
Bing Luo
机构：
[1] Qingdao University Medical College,Department of Medical Microbiology
[2] The Affiliated Hospital of Qingdao University Medical College,Department of Clinical Laboratory
[3] The Affiliated Hospital of Qingdao University Medical College,Department of Pathology Laboratory
[4] University of Pittsburgh Medical Center,Department of Pathology
来源：
Archives of Virology | 2015年 / 160卷
关键词：
Extranodal NK/T-cell lymphoma; Nasal type; EBV; Genotypes; LMP1;
D O I：
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中图分类号：
学科分类号：
摘要：
As the most common NK/T-cell lymphoma in Asian countries, extranodal NK/T-cell lymphoma, nasal type (ENKTL), has unique clinical features and a strong association with Epstein-Barr virus (EBV). In order to gain a preliminary understanding of the relationship between ENKTL and EBV, we performed genotypic analysis of EBV and investigated LMP1 expression in extranodal NK/T-cell lymphoma. Our study shows that ENKTL is an EBV-associated malignancy and that A, C and F are the predominant EBV genotypes in northern China. LMP1 expression is stronger in extranasal sites than nasal sites, and the expression level is strongly correlated to ENKTL and may play an important role in the development of ENKTL.
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页码：2071 / 2074
页数：3
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