Pulsed Dendritic Cells for the Therapy of Experimental Glioma

被引：0
作者：
I. V. Chekhonin
O. I. Gurina
S. A. Cherepanov
M. A. Abakumov
K. P. Ionova
D. K. Zhigarev
A. V. Makarov
V. P. Chekhonin
机构：
[1] Ministry of Health of the Russian Federation,V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology
[2] N. I. Pirogov Russian National Research Medical University,Department of Medical Nanobiotechnologies, Medical Biological Faculty
[3] Ministry of Health of the Russian Federation,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2016年 / 161卷
关键词：
dendritic cells; glioma; neurospecific proteins; angiogenesis; periglioma zone;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We obtained the morphologically, cytofluorometrically, and functionally mature dendritic cells from rats that were pulsed with antigens of the C6 glioma tissue extract. The concentrations of angiogenesis antigens (VEGF, VEGFR-1, and VEGFR-2) and periglioma zone proteins (GFAP, connexin 43, and BSAT1) in the pulsing extract were measured by ELISA. Our results drove us to a conclusion that despite mature phenotype of pulsed dendritic cell, the antigenic composition of glioma tissue extracts should be modified.
引用
收藏
页码：792 / 796
页数：4
相关论文
共 50 条
[41]   The evolving role of dendritic cells in cancer therapy [J].
Ilett, E. J. ;
Prestwich, R. J. D. ;
Melcher, A. A. .
EXPERT OPINION ON BIOLOGICAL THERAPY, 2010, 10 (03) :369-379
[42]   Dendritic cells: Potential role in cancer therapy [J].
Edgar G. Engleman .
Cytotechnology, 1997, 25 :1-8
[43]   Dendritic cells: Potential role in cancer therapy [J].
Engleman, EG .
CYTOTECHNOLOGY, 1997, 25 (1-3) :1-8
[44]   Enhancement of antitumor immune response in glioma models in mice by genetically modified dendritic cells pulsed with Semliki Forest virus-mediated complementary DNA [J].
Yamanaka, R ;
Zullo, SA ;
Tanaka, R ;
Blaese, M ;
Xanthopoulos, KG .
JOURNAL OF NEUROSURGERY, 2001, 94 (03) :474-481
[45]   Development of dendritic cells and their use in tumor therapy [J].
Björck, P .
CLINICAL IMMUNOLOGY, 1999, 92 (02) :119-127
[46]   Vaccination of recurrent glioma patients with tumour lysate-pulsed dendritic cells elicits immune responses: results of a clinical phase I/II trial [J].
R Yamanaka ;
T Abe ;
N Yajima ;
N Tsuchiya ;
J Homma ;
T Kobayashi ;
M Narita ;
M Takahashi ;
R Tanaka .
British Journal of Cancer, 2003, 89 :1172-1179
[47]   Vaccination of recurrent glioma patients with tumour lysate-pulsed dendritic cells elicits immune responses: results of a clinical phase I/II trial [J].
Yamanaka, R ;
Abe, T ;
Yajima, N ;
Tsuchiya, N ;
Tsuchiya, N ;
Homma, J ;
Kobayashi, T ;
Narita, M ;
Takahashi, M ;
Tanaka, R .
BRITISH JOURNAL OF CANCER, 2003, 89 (07) :1172-1179
[48]   Dendritic Cells: A Critical Player in Cancer Therapy? [J].
Palucka, Anna Karolina ;
Ueno, Hideki ;
Fay, Joseph ;
Banchereau, Jacques .
JOURNAL OF IMMUNOTHERAPY, 2008, 31 (09) :793-805
[49]   Tolerogenic dendritic cells as a therapy for treating lupus [J].
Llanos, Carolina ;
Pablo Mackern-Oberti, Juan ;
Vega, Fabian ;
Jacobelli, Sergio H. ;
Kalergis, Alexis M. .
CLINICAL IMMUNOLOGY, 2013, 148 (02) :237-245
[50]   Exosome-loaded dendritic cells elicit tumor-specific CD8+ cytotoxic T cells in patients with glioma [J].
Bu, Ning ;
Wu, Haiqin ;
Sun, Bingzhong ;
Zhang, Guilian ;
Zhan, Shuqin ;
Zhang, Ru ;
Zhou, Le .
JOURNAL OF NEURO-ONCOLOGY, 2011, 104 (03) :659-667
12345