PS13 - 66. The type 1 diabetes associated HLA-DQ8-transdimer accommodates a unique islet peptide repertoire

被引：0

作者：

Menno van Lummel

Peter A. van Veelen

Arnaud Zaldumbide

Arnoud de Ru

George M.C. Janssen

Antonis K. Moustakas

George K. Papadopoulos

Jan W. Drijfhout

Bart O. Roep

Frits Koning

机构：

[1] Leiden University Medical Center,Department of Immunohematology and Blood Transfusion

[2] Leiden University Medical Center,Department of Molecular Cell Biology

[3] Technological Educational Institute of Ionian Islands,Department of Organic Farming

[4] Faculty of Agricultural Technology,Laboratory of Biochemistry and Biophysics

[5] Epirus Institute of Technology,undefined

来源：

Nederlands Tijdschrift voor Diabetologie | 2011年 / 9卷 / 3期

关键词：

Peptide; Binding Assay; Binding Motif; Genetic Research; Peptide Binding;

D O I：

10.1007/s12467-011-0091-7

中图分类号：

学科分类号：

摘要：

In spite of the promise of decades of genetic research and the recently hyped expectations following genome-wide association studies in T1D, it remains unknown why HLADQ2 and HLA-DQ8 are strongly predisposing haplotypes for T1D. We understand even less why HLA-DQ2/8 heterozygous individuals have a synergistically increased risk compared to HLA-DQ2 or HLA-DQ8 homozygote subjects that may result from the presence of a transdimer formed between the α-chain of HLA-DQ2 (DQA1*0501) and the β-chain of HLA-DQ8 (DQB1*0302) that may bind and present unique autoantigen derived diabetogenic epitopes.

引用

页码：135 / 136

页数：1

共 3 条

[1] Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer-Restricted CD4+ T Cells Infiltrate Islets in Type 1 Diabetes
Pathiraja, Vimukthi
Kuehlich, Janine P.
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Loudovaris, Thomas
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DIABETES, 2015, 64 (01) : 172 - 182
[2] Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes
Chow, I-Ting
Gates, Theresa J.
Papadopoulos, George K.
Moustakas, Antonis K.
Kolawole, Elizabeth M.
Notturno, Richard J.
McGinty, John W.
Torres-Chinn, Nadia
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Greenbaum, Carla
Nepom, Gerald T.
Evavold, Brian D.
Kwok, William W.
SCIENCE ADVANCES, 2019, 5 (08)
[3] SELF-PEPTIDES BOUND TO THE TYPE-I DIABETES-ASSOCIATED CLASS-II MHC MOLECULES HLA-DQ1 AND HLA-DQ8
CHICZ, RM
LANE, WS
ROBINSON, RA
TRUCCO, M
STROMINGER, JL
GORGA, JC
INTERNATIONAL IMMUNOLOGY, 1994, 6 (11) : 1639 - 1649

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