Indirect determination of the microsomal oxidase activity of hepatocytes and the effect of ximedone on this activity during streptococcal angina

被引：0

作者：

Garmonov S.Yu. ^{[1
]}

Kravchenko I.E. ^{[2
]}

Shitova N.S. ^{[1
]}

Yakovleva A.V. ^{[1
]}

Zaripova R.G. ^{[2
]}

Fazylov V.Kh. ^{[2
]}

机构：

[1] Kazan State Technological University, Kazan, Tatarstan

[2] Kazan State Medical University, Kazan, Tatarstan

来源：

Pharmaceutical Chemistry Journal | 2008年 / 42卷 / 12期

关键词：

Antipyrine; Drug Elimination; Test Tissue; Phenazone; Angina Patient;

D O I：

10.1007/s11094-009-0219-x

中图分类号：

学科分类号：

摘要：

The parameters of antipyrine pharmacokinetics in saliva have been calculated and a method for indirect determination of the microsomal oxidase activity of hepatocytes has been developed based on evaluation of the average content of the test compound in sequential 3-h samples of saliva taken over a 12-h period of time after administration. Microsomal oxidase activity has been estimated in patients wth streptococcal angina. It is established that ximedone effectvely influences this activity and produces a positive therapeutic effect on the course of the disorder. © 2008 Springer Science+Business Media, Inc.

引用

页码：659 / 664

页数：5