Analgesic effect of corticotropin-releasing hormone: Involvement of the hypothalamic-pituitary-adrenocortical axis into its realization

被引：0
作者：
A. I. Bogdanov
N. I. Yarushkina
机构：
[1] Russian Academy of Sciences,Laboratory of Experimental Endocrinology, I. P. Pavlov Institute of Physiology
来源：
Bulletin of Experimental Biology and Medicine | 2006年 / 141卷
关键词：
corticotropin-releasing hormone; nociception; corticosterone; opioid receptor; rat;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Involvement of hypothalamic-pituitary-adrenocortical axis into the analgesic effect of corticotropin-releasing hormone after its systemic administration was studied in experiments on rats. Pharmacological blockade of the hypothalamic-pituitary-adrenocortical axis decreased the duration and degree of the analgesic effect of corticotropin-releasing hormone. This analgesic effect can be mediated via two pathways: related to hormones of the hypothalamic-pituitary-adrenocortical axis and independent of these hormones.
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页码：184 / 186
页数：2
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