The role of nitric oxide in nociception

被引：6
|
作者：
Luo Z.D. [1 ]
Cizkova D. [2 ]
机构：
[1] Department of Anesthesiology, University of California, San Diego, 92093-0818, La Jolla, CA
[2] Institute of Neurobiology, Slovak Academy of Sciences, 040 01, Soltesovej 6, Kosice
来源：
Current Review of Pain | 2000年 / 4卷 / 6期
基金：
美国国家卫生研究院;
关键词：
Nitric Oxide; Dorsal Root Ganglion; Neuropathic Pain; Capsaicin; Dorsal Horn;
D O I：
10.1007/s11916-000-0070-y
中图分类号：
学科分类号：
摘要：
Pharmacologic, electrophysiologic, and immunohistochemical studies have suggested a role of nitric oxide (NO) in nociception processing. Recent studies have indicated that NO may modulate spinal and sensory neuron excitability through multiple mechanisms that may underlie its distinctive roles in different pain states. Differential regulation of a family of NO-producing enzymes, NO synthases, contributes mainly to the complexity underlying the role of NO in nociception. This review summarizes the latest advances in our understanding of the contribution of NO to pain transduction. Possible cellular mechanisms regarding the connection between NO production and the abnormal sensation derived from different stimuli and pathologic conditions are discussed.
引用
收藏
页码：459 / 466
页数：7
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