Immunomodulatory activity of a water-soluble polysaccharide extracted from mussel on cyclophosphamide-induced immunosuppressive mice models

被引：0
作者：
Xingwei Xiang
Rui Wang
Lin Chen
Yufeng Chen
Bin Zheng
Shanggui Deng
Shulai Liu
Peilong Sun
Guoxin Shen
机构：
[1] Zhejiang University of Technology,College of Food Science and Technology
[2] Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province,Collaborative Innovation Center of Seafood Deep Processing
[3] National R&D Branch Center for Pelagic Aquatic Products Processing (Hangzhou),Sericultural and Tea Institute
[4] Dalian Polytechnic University,Food and Pharmacy College
[5] Zhejiang Academy of Agricultural Sciences,undefined
[6] Zhejiang Ocean University,undefined
来源：
npj Science of Food | / 6卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This study aimed to investigate the protective effect of mussel polysaccharide (MP) on cyclophosphamide (Cy)-induced intestinal mucosal immunosuppression and microbial dysbiosis in mice. MP was shown to stimulate secretion of cytokines (SIgA, IL-2, IF-γ, IL-4, IL-10) and production of transcription factors (occludin, claudin-1, ZO-1, mucin-2, IL-2, IF-γ, IL-4, IL-10). Key proteins (p-IκB-α, p-p65) of the NF-κB pathway were upregulated after MP administration. SCFAs levels, which were decreased after the Cy treatment, were improved after treatment with MP. Furthermore, 16 S rRNA sequencing data of fecal samples revealed, through α-diversity and β-diversity analysis, that MP improved microbial community diversity and modulate the overall composition of gut microbiota. Taxonomic composition analysis showed that MP increased the abundance of probiotics species (Lactobacillus) and decreased the proportion of pathogenic species (Desulfovibrio). These findings suggested that MP has a potential immunomodulatory activity on the immunosuppressive mice.
引用
收藏
相关论文
共 106 条
  • [1] Lin X(2020)Ameliorate effect of pyrroloquinoline quinone against cyclophosphamide-induced nephrotoxicity by activating the Nrf2 pathway and inhibiting the NLRP3 pathway Life Sci. 256 117901-1131
  • [2] Xue R(2020)Polysaccharides from hemp seed protect against cyclophosphamide-induced intestinal oxidative damage via Nrf2-Keap1 signaling pathway in mice Oxid. Med. Cell. Longev. 2020 1813798-1023
  • [3] Ying M(2020)Cultured Cordyceps sinensis polysaccharides modulate intestinal mucosal immunity and gut microbiota in cyclophosphamide-treated mice Carbohydr. Polym. 235 115957-71
  • [4] Li C(2020)Fucoidan from sea cucumber Holothuria polii: structural elucidation and stimulation of hematopoietic activity Int. J. Biol. Macromol. 154 1123-1114
  • [5] Huo J(2020)Immunomodulatory activity of a novel polysaccharide extracted from Huangshui on THP-1 cells through NO production and increased IL-6 and TNF-alpha expression Food Chem. 330 127257-927
  • [6] Ren Z(2019)Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma Gut 68 1014-12
  • [7] Fan Y(2021)Gut microbiota in human metabolic health and disease Nat. Rev. Microbiol. 19 55-255
  • [8] Pedersen O(2021)Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARgamma signaling activation Microbiome 9 1108-3315
  • [9] Li D(2019)Role of the microbiome in human development Gut 68 915-121
  • [10] Dominguez-Bello MG(2021)Western-type diet influences mortality from necrotising pancreatitis and demonstrates a central role for butyrate Gut 70 0-70
12345678910