Antibodies to Glutamate Facilitate Spatial Memory Formation in the Morris Water Maze in Aging C57BL/6 mice

被引：0
作者：
T. V. Davydova
M. A. Gruden
V. S. Kudrin
V. B. Narkevich
L. A. Vetrile
I. A. Zakharova
R. D. E. Sewell
机构：
[1] Research Institute of General Pathology and Pathophysiology,School of Pharmacy and Pharmaceutical Sciences
[2] P. K. Anokhin Research Institute of Normal Physiology,undefined
[3] V. V. Zakusov Research Institute of Pharmacology,undefined
[4] Cardiff University,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2020年 / 169卷
关键词：
aging; memory; antibodies to glutamate; neurotransmitters;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Intranasal administration of antibodies to glutamate in a dose of 250 μg/kg for two weeks facilitated spatial learning and memory formation in the Morris water maze in aging C57BL/6 mice. In animals treated with glutamate antibodies, the content of serotonin and dopamine metabolites 3-MT and HVA in the hippocampus decreased, but no changes in the metabolism of neurotransmitter acids were revealed. In the prefrontal cortex, dopamine level decreased and the content of its metabolite DOPAC increased; in parallel, an increase in excitatory and inhibitory amino acids (aspartic acid, glutamate, glycine, taurine, and GABA) was observed.
引用
收藏
页码：5 / 8
页数：3
相关论文
共 51 条
  • [1] Gruden MA(2017)Neuroprotective effects of glutamate antibodies on memory impairment induced by proinflammatory S100A9 protein oligomers in aging animals Patol. Fiziol. Eksp. Ter. 61 13-20
  • [2] Davydova TV(2019)Effect of Antibodies to Glutamate on Age-Related Memory Changes in C57BL/6 Mice Bull. Exp. Biol. Med. 166 326-329
  • [3] Kudrin VS(2018)The Influence of Noopept on Morphological, Electrophysiological, and Biochemical Changes in the Retina during the Experimental Thrombosis of Its Vessels Neirokhimiya. 35 70-76
  • [4] Narkevich VB(2015)Taurine increases hippocampal neurogenesis in aging mice Stem Cell Res. 14 369-379
  • [5] Vetrile LA(2018)S100A9 Protein Aggregates Boost Hippocampal Glutamate Modifying Monoaminergic Neurochemistry: A Glutamate Antibody Sensitive Outcome on Alzheimer-like Memory Decline ACS Chem. Neurosci. 9 568-577
  • [6] Morozova-Roche LA(2016)The misfolded pro-inflammatory protein S100A9 disrupts memory via neurochemical remodelling instigating an Alzheimer’sec disease-like cognitive deficit Behav. Brain Res. 306 106-116
  • [7] Sewell RDE(2014)Tang S, Meng ZJ, He YY, Song LY, Liu YP, Ma N, Li XY Guo SC. Taurine improves the spatial learning and memory ability impaired by sub-chronic manganese exposure. J. Biomed. Sci. 21 51-608
  • [8] Davydova TV(2005)Does the human leukaemia differentiation factor fragment HLDF6 improve memory via brain DNA and protein synthesis? J Psychopharmacol. 19 602-undefined
  • [9] Gruden MA(undefined)undefined undefined undefined undefined-undefined
  • [10] Kudrin VS(undefined)undefined undefined undefined undefined-undefined
123456