Tumor Necrosis Factor-α Gene Polymorphisms in Korean Patients With Recurrent Spontaneous Abortion

被引：0
作者：
Bo Eun Lee
Young Joo Jeon
Ji Eun Shin
Ji Hyang Kim
Dong Hee Choi
Yong Wook Jung
Sung Han Shim
Woo Sik Lee
Nam Keun Kim
机构：
[1] CHA University,Institute for Clinical Research, CHA Bundang Medical Center
[2] College of Life Science,Department of Biomedical Science
[3] CHA University,Department of Obstetrics and Gynecology, CHA Bundang Medical Center
[4] CHA University,Department of Obstetrics and Gynecology, CHA Gangnam Medical Center
[5] CHA University School of Medicine,Fertility Center of CHA Gangnam Medical Center
[6] CHA University,undefined
来源：
Reproductive Sciences | 2013年 / 20卷
关键词：
tumor necrosis factor-α; recurrent spontaneous abortion; polymorphism; risk factor;
D O I：
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学科分类号：
摘要：
The objective of this study was to investigate the contribution of the tumor necrosis factor-α (TNF-α) gene polymorphisms to recurrent spontaneous abortion (RSA). The study participants consisted of 357 Korean women with RSA and 236 fertile women controls. Four TNF-α gene variants of all participants were analyzed by polymerase chain reaction–restriction fragment length polymorphism assay. The TNF-α -1031T>C and TNF-α -238G>A variants increased the risk of RSA TNF-α -1031TC+CC; adjusted odds ratio [AOR], 2.292; 95% confidence interval [CI], 1.547-3.395; P < .001; TNF-α -238GA+AA; AOR, 2.327; 95% CI, 1.038-5.217; P = .040), and these data were not different in a stratified analysis according to the number of consecutive spontaneous abortions. Also, the mutant genotypes of TNF-α -1031 and TNF-α -238 showed synergistic effects on increased RSA risk (-1031TC+CC/-238GA+AA; AOR, 4.054; 95% CI, 1.520-10.812; P = .005). In haplotype analysis, there were similar trends of data for combination analysis. In conclusion, the TNF-α -1031T>C and TNF-α -238G>A variants are possible genetic risk factors for RSA.
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页码：408 / 413
页数：5
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