Survival outcomes and clinical benefit in patients with acute myeloid leukemia treated with glasdegib and low-dose cytarabine according to response to therapy

被引:0
作者
Jorge E. Cortes
Florian H. Heidel
Walter Fiedler
B. Douglas Smith
Tadeusz Robak
Pau Montesinos
Anna Candoni
Brian Leber
Mikkael A. Sekeres
Daniel A. Pollyea
Roxanne Ferdinand
Weidong Wendy Ma
Thomas O’Brien
Ashleigh O’Connell
Geoffrey Chan
Michael Heuser
机构
[1] Georgia Cancer Center,Department of Hematology and Oncology
[2] Otto-von-Guericke University Medical Center Magdeburg,Department of Hematology
[3] Internal Medicine II,Leukemia Program
[4] University Hospital Jena,Division of Hematology
[5] University Hospital Hamburg-Eppendorf,Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation
[6] Johns Hopkins Sidney Kimmel Comprehensive Cancer Center,undefined
[7] Medical University of Łódź and Copernicus Memorial Hospital,undefined
[8] Hospital Universitari i Politècnic La Fe,undefined
[9] Valencia,undefined
[10] Spain; CIBERONC,undefined
[11] Instituto Carlos III,undefined
[12] Azienda Sanitaria Universitaria Integrata di Udine,undefined
[13] Juravinski Hospital at Hamilton Health Sciences,undefined
[14] Cleveland Clinic,undefined
[15] University of Colorado School of Medicine,undefined
[16] Pfizer Oncology,undefined
[17] Hannover Medical School,undefined
来源
Journal of Hematology & Oncology | / 13卷
关键词
Glasdegib; Acute myeloid leukemia; Clinical trial; Disease response; Efficacy;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 85 条
[1]  
Cortes JE(2019)Randomized comparison of low dose cytarabine with or without glasdegib in patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome Leukemia. 33 379-389
[2]  
Heidel FH(2009)Hedgehog signaling is dispensable for adult hematopoietic stem cell function Cell Stem Cell. 4 548-558
[3]  
Hellmann A(2016)Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells Cancer Sci. 107 1422-1429
[4]  
Fiedler W(2009)Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia Nature. 458 776-779
[5]  
Smith BD(2009)Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis Cell Stem Cell. 4 559-567
[6]  
Robak T(2003)Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia J Clin Oncol. 21 4642-4649
[7]  
Gao J(2019)Enasidenib, an inhibitor of mutant IDH2 proteins, induces durable remissions in older patients with newly diagnosed acute myeloid leukemia Leukemia. 33 2575-2584
[8]  
Graves S(2019)Venetoclax combined with low-dose cytarabine for previously untreated patients with acute myeloid leukemia: results from a phase Ib/II study J Clin Oncol. 37 1277-1284
[9]  
Koch U(2015)International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts Blood. 126 291-299
[10]  
Liu S(2017)Therapeutic targeting of acute myeloid leukemia stem cells Blood. 129 1627-1635