Therapeutic Strategies for Hereditary Kidney Cancer

被引：0
作者：
Abhinav Sidana
Ramaprasad Srinivasan
机构：
[1] National Cancer Institute,Urologic Oncology Branch, Center for Cancer Research
来源：
Current Oncology Reports | 2016年 / 18卷
关键词：
Renal cell cancer; Hereditary; Inherited; Kidney cancer; Clear cell renal cell cancer; Papillary renal cell cancer; Tyrosine kinase inhibitors; Von Hippel-Lindau; HLRCC; HPRC; Tuberous sclerosis; Metastatic; Fumarate hydratase; Succinate dehydrogenase;
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摘要：
The study of hereditary forms of kidney cancer has vastly increased our understanding of metabolic and genetic pathways involved in the development of both inherited and sporadic kidney cancers. The recognition that diverse molecular events drive different forms of kidney cancers has led to the preclinical and clinical development of specific pathway-directed strategies tailored to treat distinct subgroups of kidney cancer. Here, we describe the molecular mechanisms underlying the pathogenesis of several different types of hereditary renal cancers, review their clinical characteristics, and summarize the treatment strategies for the management of these cancers.
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