Vitamin A Deficiency in Patients with Common Variable Immunodeficiency

被引：0
作者：
Sara Sebnem Kilic
Esra Yapici Kezer
Yesim Ozarda Ilcol
Tahsin Yakut
Sami Aydin
Ismail Hakki Ulus
机构：
[1] Uludag University School of Medicine,Department of Pediatric Immunology
[2] Uludag University School of Medicine,Department of Biochemistry and Clinical Biochemistry
[3] Uludag University School of Medicine,Department of Medical Genetics
[4] Uludağ University School of Medicine,Department of Pharmacology and Clinical Pharmacology
[5] Uludag University Medical Faculty,Department of Pediatrics
来源：
Journal of Clinical Immunology | 2005年 / 25卷
关键词：
Vitamin A; common variable immunodeficiency; cytokine; neopterin;
D O I：
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中图分类号：
学科分类号：
摘要：
Vitamin A, a naturally occuring antioxidant micronutrient, has immunomodulating effect in patients with immunodeficiency, including an influence on cytokine production and lymphocyte growth and functions. Vitamin A deficiency is associated with a shift from type 2 cytokines to predominantly type 1 cytokines. The aims of this study were to determine Vitamin A status in Common variable immunodeficiency (CVID) patients and the relationship between Vitamin A status and cytokines production. Serum Vitamin A, neopterin, TNF-alpha, IL-2, IL-4, and IL-10 levels were determined in 19 CVID patients and 15 healthy children. Effects of 9-cis retinal, Vitamin A derivative, on cytokines (TNF-alpha, IL-2, IL-4 and IL-10) production in lymphocytes were tested in vitro condition using lymphocyte cultures obtained from CVID patients and healthy children.
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页码：275 / 280
页数：5
相关论文
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