Combined administration of an mGlu2/3 receptor agonist and a 5-HT2A receptor antagonist markedly attenuate the psychomotor-activating and neurochemical effects of psychostimulants

被引:0
作者
Jason M. Uslaner
Sean M. Smith
Sarah L. Huszar
Rashida Pachmerhiwala
Richard M. Hinchliffe
Joshua D. Vardigan
Pete H. Hutson
机构
[1] Merck & Co.,Department of Schizophrenia Research
[2] Inc.,undefined
来源
Psychopharmacology | 2009年 / 206卷
关键词
Amphetamine; MK-801; Dopamine; Norepinephrine; Psychostimulant; Locomotor activity; Antipsychotic; Schizophrenia;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:641 / 651
页数:10
相关论文
共 205 条
[1]  
Adams BW(2001)Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex Biol Psychiatry 50 750-757
[2]  
Moghaddam B(1995)Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of Eur J Pharmacol 283 55-62
[3]  
Arnt J(1989)-amphetamine J Neural Transm 75 221-226
[4]  
Carlsson M(2000)The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice Psychopharmacology (Berl) 148 423-429
[5]  
Carlsson A(2000)Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268 and comparison with the atypical antipsychotic, clozapine Eur J Pharmacol 400 221-224
[6]  
Cartmell J(2000)The mGlu(2/3) receptor agonist LY379268 selectively blocks amphetamine ambulations and rearing Naunyn Schmiedebergs Arch Pharmacol 361 39-46
[7]  
Monn JA(2005)Tolerance to the motor impairment, but not to the reversal of PCP-induced motor activities by oral administration of the mGlu2/3 receptor agonist, LY379268 Neuropsychopharmacology 30 1324-1333
[8]  
Schoepp DD(2002)Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonists Psychopharmacology (Berl) 163 54-61
[9]  
Cartmell J(1988)Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice Psychopharmacology (Berl) 96 521-527
[10]  
Monn JA(1969)Alpha 1- and alpha 2-adrenoreceptor antagonists differentially influence locomotor and stereotyped behaviour induced by Arch Int Pharmacodyn Ther 178 166-176