Particulate matter exposure shapes DNA methylation through the lifespan

被引:0
作者
L. Ferrari
M. Carugno
V. Bollati
机构
[1] Università degli Studi di Milano,EPIGET—Epidemiology, Epigenetics and Toxicology Lab, Department of Clinical Sciences and Community Health
来源
Clinical Epigenetics | 2019年 / 11卷
关键词
DNA methylation; Environmental exposures; Particulate matter;
D O I
暂无
中图分类号
学科分类号
摘要
Exposure to airborne particulate matter (PM) has been associated with detrimental health effects. DNA methylation represents the most well-studied epigenetic factor among the possible mechanisms underlying this association. Interestingly, changes of DNA methylation in response to environmental stimuli are being considered for their role in the pathogenic mechanism, but also as mediators of the body adaptation to air pollutants.
引用
收藏
相关论文
共 136 条
[1]  
Landrigan PJ(2018)The Lancet Commission on pollution and health Lancet 391 462-512
[2]  
Gao J(2018)Temporal-spatial characteristics and source apportionment of PM2.5 as well as its associated chemical species in the Beijing-Tianjin-Hebei region of China Environ Pollut 233 714-724
[3]  
Brook RD(2014)Hemodynamic, autonomic, and vascular effects of exposure to coarse particulate matter air pollution from a rural location Environ Health Perspect 122 624-630
[4]  
Saenen ND(2017)Children’s urinary environmental carbon load. A novel marker reflecting residential ambient air pollution exposure? Am J Respir Crit Care Med 196 873-881
[5]  
Probst AV(2009)Epigenetic inheritance during the cell cycle Nat Rev Mol Cell Biol 10 192-206
[6]  
Dunleavy E(2007)Implication of abnormal epigenetic patterns for human diseases Eur J Hum Genet 15 10-17
[7]  
Almouzni G(1991)DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein Cell 64 1123-1134
[8]  
Santos-Reboucas CB(2009)DNA hypomethylation in cancer cells Epigenomics 1 239-259
[9]  
Pimentel MM(2015)The alternative role of DNA methylation in splicing regulation Trends Genet 31 274-280
[10]  
Boyes J(2013)Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments Mutat Res 741-742 18-26