Cyclosporin A Enhances Cardiac Differentiation by Inhibiting Wnt/β-Catenin Signaling in Human Embryonic Stem Cells

被引：0
|
作者：
Mu Seog Choe
Han Cheol Yeo
Jae Boum Youm
Seung Hak Choi
Won-Young Choi
So Jin Kim
Seung Tack Oh
Ho Jae Han
Kyung Min Baek
Joong Sun Kim
Kyung Seob Lim
Woochul Chang
Min Young Lee
机构：
[1] Kyungpook National University,College of Pharmacy, Research Institute of Pharmaceutical Sciences
[2] Inje University,Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center
[3] Inje University,Department of Physiology, College of Medicine
[4] Seoul National University,Department of Veterinary Physiology, College of Veterinary Medicine
[5] Daegu Haany University,Department of Cardiovascular and Neurologic Disease, College of Oriental Medicine
[6] Korea Institute of Oriental Medicine,K
[7] Korea Research Institute of Bioscience and Biotechnology,herb Research Center
[8] Pusan National University,Futuristic Animal Resource and Research Center
来源：
Biotechnology and Bioprocess Engineering | 2021年 / 26卷
关键词：
cardiac differentiation; human embryonic stem cells; cyclosporin A; Wnt/β-catenin signaling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Efficient cardiac differentiation of human pluripotent stem cells (hPSCs) is essential for their use in the field of basic research as well as in cell-based therapy. Regulation of the Wnt/β-catenin pathway is a key step in the process of cardiac differentiation of hPSCs. In this study, we reported cyclosporin A (CsA), a strong immunosuppressor, as an inducer of cardiac differentiation in human embryonic stem cells (hESCs). Our results showed that CsA promoted cardiac differentiation in the mesodermal differentiation stage of hESCs and that this effect was mediated by the inhibition of Wnt/β-catenin signaling. Therefore, our results provide novel information about CsA as a Wnt/β-catenin inhibitor as well as a strategy for the cardiac differentiation of hESCs.
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页码：786 / 794
页数：8
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