Therapeutic role of FNDC5/irisin in attenuating liver fibrosis via inhibiting release of hepatic stellate cell-derived exosomes

[1] Tsochatzis EA(2014)Liver cirrhosis Lancet 383 1749-1761

[2] Bosch J(2018)Clinical states of cirrhosis and competing risks J Hepatol 68 563-576

[3] Burroughs AK(2017)Mechanisms of hepatic stellate cell activation Nat Rev Gastroenterol Hepatol 14 397-411

[4] D'Amico G(2011)Pathogenesis of liver fibrosis Annu Rev Pathol 6 425-456

[5] Morabito A(2017)Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets Nat Rev Gastroenterol Hepatol 14 455-466

[6] D'Amico M(2020)Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis J Hepatol 73 1144-1154

[7] Pasta L(2018)Hepatic stellate cell-derived platelet-derived growth factor receptor-alpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2 Hepatology 68 333-348

[8] Malizia G(2020)Dynamic changes in function and proteomic composition of extracellular vesicles from hepatic stellate cells during cellular activation Cells 9 290-8542

[9] Rebora P(2019)Exosomes from activated hepatic stellate cells contain GLUT1 and PKM2: a role for exosomes in metabolic switch of liver nonparenchymal cells FASEB J 33 8530-468

[10] Valsecchi MG(2012)A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis Nature 481 463-1875

[1] Tsochatzis EA(2014)Liver cirrhosis Lancet 383 1749-1761

[2] Bosch J(2018)Clinical states of cirrhosis and competing risks J Hepatol 68 563-576

[3] Burroughs AK(2017)Mechanisms of hepatic stellate cell activation Nat Rev Gastroenterol Hepatol 14 397-411

[4] D'Amico G(2011)Pathogenesis of liver fibrosis Annu Rev Pathol 6 425-456

[5] Morabito A(2017)Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets Nat Rev Gastroenterol Hepatol 14 455-466

[6] D'Amico M(2020)Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis J Hepatol 73 1144-1154

[7] Pasta L(2018)Hepatic stellate cell-derived platelet-derived growth factor receptor-alpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2 Hepatology 68 333-348

[8] Malizia G(2020)Dynamic changes in function and proteomic composition of extracellular vesicles from hepatic stellate cells during cellular activation Cells 9 290-8542

[9] Rebora P(2019)Exosomes from activated hepatic stellate cells contain GLUT1 and PKM2: a role for exosomes in metabolic switch of liver nonparenchymal cells FASEB J 33 8530-468

[10] Valsecchi MG(2012)A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis Nature 481 463-1875