The role of passive immunization in the age of SARS-CoV-2: an update

被引：16

作者：

Fischer, Johannes C. ^{[1
]}

Zanker, Kurt ^{[2
]}

van Griensven, Martijn ^{[3
,4
,5
]}

Schneider, Marion ^{[6
]}

Kindgen-Milles, Detlef ^{[7
]}

Knoefel, Wolfram Trudo ^{[8
]}

Lichtenberg, Artur ^{[9
]}

Tamaskovics, Balint ^{[10
]}

Djiepmo-Njanang, Freddy Joel ^{[10
]}

Budach, Wilfried ^{[10
]}

Corradini, Stefanie ^{[11
]}

Ganswindt, Ute ^{[10
]}

Haeussinger, Dieter ^{[12
]}

Feldt, Torsten ^{[12
]}

Schelzig, Hubert ^{[13
]}

Bojar, Hans ^{[14
]}

Peiper, Matthias ^{[15
]}

Boelke, Edwin ^{[10
]}

Haussmann, Jan ^{[10
]}

Matuschek, Christiane ^{[10
]}

机构：

[1] Heinrich Heine Univ, Inst Transplant Diagnost & Cell Therapeut, Dusseldorf, Germany

[2] Nanjing Han & Zaenker Canc Inst, Nanjing, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, Nanjing, Jiangsu, Peoples R China

[4] Nanjing Tech Univ, Peking Union Med Coll, Nanjing, Jiangsu, Peoples R China

[5] Maastricht Univ, Dept cBITE, MERLN Inst Technol Inspired Regenerat Med, Maastricht, Netherlands

[6] Univ Ulm, Dept Expt Anesthesiol, Ulm, Germany

[7] Heinrich Heine Univ, Dept Anesthesiol & Intens Care Med, Dusseldorf, Germany

[8] Heinrich Heine Univ, Dept Surg, Dusseldorf, Germany

[9] Heinrich Heine Univ, Dept Cardiac Surg, Dusseldorf, Germany

[10] Heinrich Heine Univ, Dept Radiat Oncol, Moorenstr 5, D-40225 Dusseldorf, Germany

[11] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Radiat Oncol, Munich, Germany

[12] Heinrich Heine Univ, Clin Gastroenterol Hepatol & Infect Dis, Innsbruck, Austria

[13] Heinrich Heine Univ, Dept Vasc Surg, Dusseldorf, Germany

[14] NEXTGEN ONCOL Grp, Dusseldorf, Germany

[15] Heinrich Heine Univ, Dusseldorf, Germany

来源：

EUROPEAN JOURNAL OF MEDICAL RESEARCH | 2020年 / 25卷 / 01期

关键词：

Convalescent plasma; Covid-19; High risk; Bridge therapy; Intensive care unit; Respiratory failure; Immunology; COVID-19;

D O I：

10.1186/s40001-020-00414-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The rapid spread of the corona virus pandemic is an existential problem for many people in numerous countries. So far, there is no effective vaccine protection or proven therapy available against the SARS-CoV-2 virus. In this review, we describe the role of passive immunization in times of the corona virus. Passive immunization could be a bridging technology to improve the immune defense of critically ill patients until better approaches with effective medications are available.

引用

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