Improving lipase-catalyzed enantioselective ammonolysis of phenylglycine methyl ester in organic solvent by in situ racemization

被引：0
作者：
Wei Du
Minhua Zong
Yong Guo
Dehua Liu
机构：
[1] Tsinghua University,Department of Chemical Engineering
[2] South China University of Technology,Department of Biotechnology
来源：
Biotechnology Letters | 2003年 / 25卷
关键词：
ammonolysis; enantioselective; racemization; lipase; phenylglycine methyl ester;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Lipase-catalyzed enantioselective ammonolysis of phenylglycine methyl ester was processed by in situ racemization with ammonium carbamate as the acyl acceptor. Using 1 mM benzaldehyde or 0.6 mM chloropyridoxal as the racemizing catalyst, 80% substrate conversion with an enantiomeric excess of the product of 95% were achieved at 20 °C after 7 h reaction.
引用
收藏
页码：461 / 464
页数：3
相关论文
共 50 条
  • [1] Improving lipase-catalyzed enantioselective ammonolysis of phenylglycine methyl ester in organic solvent by in situ racemization
    Du, W
    Zong, MH
    Guo, Y
    Liu, DH
    BIOTECHNOLOGY LETTERS, 2003, 25 (06) : 461 - 464
  • [2] Lipase-catalysed enantioselective ammonolysis of phenylglycine methyl ester in organic solvent
    Du, W
    Zong, MH
    Guo, Y
    Liu, DH
    BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2003, 38 (38) : 107 - 110
  • [3] Lipase-catalyzed ammonolysis of trimethylsilylmethyl acetate in organic solvent
    Peng, HS
    Zong, MH
    Wang, JF
    Xu, YQ
    BIOCATALYSIS AND BIOTRANSFORMATION, 2004, 22 (03) : 183 - 187
  • [4] Improvement of the enantioselectivity of lipase-catalyzed naproxen ester hydrolysis in organic solvent
    Xin, JY
    Li, SB
    Chen, XH
    Wang, LL
    Xu, Y
    ENZYME AND MICROBIAL TECHNOLOGY, 2000, 26 (2-4) : 137 - 141
  • [5] Lipase-catalyzed enantioselective esterification of (S)-naproxen hydroxyalkyl ester in organic media
    Chun-Sheng Chang
    Chin-Shuo Hsu
    Biotechnology Letters, 2003, 25 : 413 - 416
  • [6] Lipase-catalyzed enantioselective esterification of (S)-naproxen hydroxyalkyl ester in organic media
    Shang, CS
    Hsu, CS
    BIOTECHNOLOGY LETTERS, 2003, 25 (05) : 413 - 416
  • [7] Lipase-catalyzed enantioselective esterification of S(+)-naproxen ester prodrugs in cyclohexane
    Tsai, SW
    Lin, SF
    Chang, CS
    JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 1999, 74 (08) : 751 - 758
  • [8] Lipase-catalyzed esterification in organic solvent to resolve racemic naproxen
    Y.-m. Cui
    D.-z. Wei
    J.-t. Yu
    Biotechnology Letters, 1997, 19 : 865 - 868
  • [9] Reaction equilibrium for lipase-catalyzed condensation in organic solvent systems
    Kobayashi, T
    Adachi, S
    BIOTECHNOLOGY LETTERS, 2004, 26 (19) : 1461 - 1468
  • [10] ENANTIOSELECTIVE LIPASE-CATALYZED ESTER HYDROLYSIS - EFFECTS ON RATES AND ENANTIOSELECTIVITY FROM A VARIATION OF THE ESTER STRUCTURE
    BOJARSKI, J
    OXELBARK, J
    ANDERSSON, C
    ALLENMARK, S
    CHIRALITY, 1993, 5 (03) : 154 - 158
12345