Improving lipase-catalyzed enantioselective ammonolysis of phenylglycine methyl ester in organic solvent by in situ racemization

被引：0
|
作者：
Wei Du
Minhua Zong
Yong Guo
Dehua Liu
机构：
[1] Tsinghua University,Department of Chemical Engineering
[2] South China University of Technology,Department of Biotechnology
来源：
Biotechnology Letters | 2003年 / 25卷
关键词：
ammonolysis; enantioselective; racemization; lipase; phenylglycine methyl ester;
D O I：
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中图分类号：
学科分类号：
摘要：
Lipase-catalyzed enantioselective ammonolysis of phenylglycine methyl ester was processed by in situ racemization with ammonium carbamate as the acyl acceptor. Using 1 mM benzaldehyde or 0.6 mM chloropyridoxal as the racemizing catalyst, 80% substrate conversion with an enantiomeric excess of the product of 95% were achieved at 20 °C after 7 h reaction.
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页码：461 / 464
页数：3
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