The Role of Energy Balance in Cancer Prevention

被引：0
|
作者：
Marian L. Neuhouser
Martine M. Perrigue
机构：
[1] Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, 1100 Fairview Avenue North
来源：
Current Nutrition Reports | 2012年 / 1卷 / 1期
关键词：
Breast cancer; Caloric restriction; Cancer; Cancer prevention; Cancer risk; Colorectal cancer; Energy balance; Energy restriction; Gynecological cancer; Obesity; Overweight; Thyroid cancer; Weight loss;
D O I：
10.1007/s13668-011-0001-z
中图分类号：
学科分类号：
摘要：
Nearly two thirds of American adults are overweight or obese, placing them at increased risk of obesity-related chronic diseases, including cancer. Although it has been known for quite some time that obesity increases initial risk of breast, colon, and endometrial cancer, new data implicate obesity as a risk factor for ovarian and thyroid cancers. In addition, recent evidence shows that obesity is associated with poor survival from most cancers. Obesity influences several biological pathways, including those related to glucose homeostasis, insulin-like growth factor signaling, and inflammation. Dysregulation of these pathways in obesity may provide the biological link between obesity and carcinogenesis. © 2012 Springer Science+Business Media, LLC.
引用
收藏
页码：8 / 15
页数：7
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