Stress-Induced Increases in Levels of Caspases in the Prefrontal Cortex in a Rat Model of PTSD

被引：0
作者：
J. H. Zhang
M. Li
F. Han
Yu X. Shi
机构：
[1] China Medical University,Department of Histology and Embryology, Basic Medical Sciences College
[2] China Medical University,Institute of Pathology and Pathophysiology
[3] North Hospital,Department of Neurology
来源：
Neurophysiology | 2016年 / 48卷
关键词：
caspase-3; caspase-9; medial prefrontal cortex; single prolonged stress; post-traumatic stress disorder (PTSD);
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We investigated the levels of expression of caspase-3 and 9 in the medial prefrontal cortex (mPFC) of rats subjected to single prolonged stress (SPS) to provide a novel insight into the mechanism of how this cortical region is related to post-traumatic stress disorder (PTSD). Fifty male Wistar rats were divided into the control group and four SPS groups examined at days 1, 4, 7, and 14 after treatment. Expression of caspase-3 in SPS groups was significantly greater when compared with the control group (P < 0.05) and peaked at day 7 after exposure to SPS. In the control group, the intensity of fluorescence of caspase-9-positive cells was low, while that in the SPS groups was significantly higher (P < 0.01) and peaked at day 4 after exposure to SPS. After SPS episodes, levels of mRNA of caspase-3 and caspase-9, compared with those in the control group, gradually increased and peaked at days 7 and 4, respectively (P < 0.01). Therefore, changes of expression of caspase-9 and caspase-3 may play an important role in the pathogenesis of PTSD.
引用
收藏
页码：11 / 16
页数：5
相关论文
共 51 条
[1]  
Cahill L(1998)Mechanisms of emotional arousal and lasting declarative memory Trends Neurosci. 21 294-299
[2]  
McGaugh JL(1998)Proteases to die for Genes Dev. 12 1551-1570
[3]  
Cryns V(2009)Stress: a neurobiological perspective Tijdschr. Psychiat. 51 541-550
[4]  
Yuan J(2009)Stress, trauma, and post-traumatic stress disorder Tijdschr. Psychiat. 51 595-602
[5]  
de Kloet ER(1995)Emotion: clues from the brain Annu. Rev. Psychol. 46 209-235
[6]  
Vermetten E(1996)Projections of the medial and lateral prefrontal cortices to the amygdala: a Neuroscience 71 55-75
[7]  
LeDoux JE(2009) leucoagglutinin study in the rat Neuropsychopharmacology 35 169-191
[8]  
McDonald AJ(2007)The Neurocircuitry of fear, stress, and anxiety disorders Prog. Neuropsychopharmacol. Biol. Psychiat. 31 642-651
[9]  
Mascagni F(2004)Single prolonged stress increases contextual freezing and the expression of glycine transporter 1 and vesicle-associated membrane protein 2 mRNA in the hippocampus of rats Psychopharmacology 172 225-229
[10]  
Guo L(2006)Topiramate attenuates exaggerated acoustic startle in an animal model of PTSD Psychopharmacology 189 165-173
123456