Seroepidemiology of hepatitis A in Delhi

被引：11

作者：

Dutta A.K. ^{[1
]}

Aggarwal A. ^{[1
,3
]}

Kapoor A.K. ^{[2
]}

Ray G.N. ^{[2
]}

Batra S. ^{[2
]}

机构：

[1] Department of Pediatrics, Kalawati Saran Children's Hospital, Lady Hardinge Medical College, New Delhi

[2] Department of Biochemistry, Kalawati Saran Children's Hospital, Lady Hardinge Medical College, New Delhi

[3] Block - C2B, Janakpuri

来源：

The Indian Journal of Pediatrics | 2000年 / 67卷 / 2期

关键词：

Anti - HAV antibodies; Hepatitis A; Seroepidemiology;

D O I：

10.1007/BF02726169

中图分类号：

学科分类号：

摘要：

A prospective study was done to determine the age specific prevalence of antihepatitis A antibodies (anti HAV Abs) among children in Delhi. Four hundred and twenty children aged 0-12 years attending outpatient department for vaccination or any minor illness were studied. Sera was tested by ELISA for anti HAV Abs using a commercial kit (Hepvase A 96 TMB). Thirty samples of cord blood were similarly analyzed. All samples of cord blood were positive for anti HAV Abs. Prevalence of anti HAV Abs was 80% by 5 years of age. The most vulnerable age group was 0.5-1.5 years (anti HAV Ab positivity). Cord blood had 100% positivity. Univariate and multivariate analyses taking anti HAV antibody positivity as dependant variable demonstrated that age and father's education (socioeconomic status) significantly affect prevalence of anti HAV Abs. Sex, water supply, history of jaundice in self or family did not have any significant effect on anti HAV antibody positivity. Prevalence of anti HAV antibodies is 80% by 5 years of age. Further studies in different strata of society and different regions in the country are required to assess the need and age for vaccination.

引用

页码：77 / 79

页数：2

共 10 条

[1]

Melnick, J.L., History and epidemiology of Hepatitis A virus (1995) J Pediatr Inf Dis, 1171 (1 SUPPL.), pp. 52-58

[2]

Thapa, B.R., Singh, K., Singh, V., Patterns of Hepatitis A and B virus markers in cases of acute sporadic hepatitis and in healthy school children from North West India (1995) J Trop Pediatr, 41, pp. 328-329

[3]

Tandon, B.N., Gandhi, M.B., Joshi, Y.K., Etiological spectrum of viral hepatitis and prevalence of markers of hepatitis A and B virus infection in North India (1984) Bull WHO, 62 (1), pp. 67-73

[4]

Hollinger, F.B., Theodore, E., Gershon, A., Jong, E.C., Koff, R.S., Discussion: Who should receive Hepatitis A (Vaccine). A strategy for controlling hepatitis a (1995) J Infect Dis, 171 (SUPPL.), pp. 573-577

[5]

Arankalle, V.A., Tsarev, S.A., Chadha, M.S., Age specific prevalence of antibodies to hepatitis A and E virus in Pune. India 1982 and 1992 (1995) J Infect Dis, 171 (2), pp. 447-450

[6]

(1972) Report. Indian Pediatr, 9, pp. 360-368

[7]

Gandhi, B.M., Joshi, Y.K., Tandon, B.N., Prevalence of virus a exposure and viral hepatitis A in India (1981) Lancet, (2), pp. 374-375

[8]

Yap, I., Guan, R., Hepatitis A seroepidemiology in Singapore, a changing pattern (1993) Trans Royal Society Trop Med, 87, pp. 22-23

[9]

Lim, D.S., Cho, K.H., Kim, H.C., Seroepidemiological study of Anti-HAV antibody in Cheonbuk Province in 1989 (1992) Korean J Int Med, 43, pp. 43-46

[10]

Heng, B.H., Goh, K.T., Doriasingham, S., Quek, G.H., Prevalence of hepatitis A infection among sewage workers in Singapore (1994) Epidemiol Infect, 113, pp. 121-128

← 1 →