Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor ligands

[1] Lagerstrom MC(2008)Structural diversity of G protein-coupled receptors and significance for drug discovery Nat Rev Drug Discovery 7 339-357

[2] Schioth HB(2021)GPCRdb in 2021: integrating GPCR sequence, structure and function Nucleic Acids Res 49 D335-D343

[3] Kooistra AJ(2015)GLASS: a comprehensive database for experimentally validated GPCR-ligand associations Bioinformatics 31 3035-3042

[4] Mordalski S(2018)G protein-coupled receptors as targets for approved drugs: how many targets and how many drugs? Mol Pharmacol 93 251-258

[5] Pándy-Szekeres G(2019)BitterDB: taste ligands and receptors database in 2019 Nucleic Acids Res 47 D1179-D1185

[6] Esguerra M(2014)The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14 FASEB J 28 1181-1197

[7] Chan WK(2017)Bitterness prediction in-silico: a step towards better drugs Int J Pharm 536 526-529

[8] Zhang H(2021)Intense bitterness of molecules: machine learning for expediting drug discovery Comput Struct Biotechnol J 19 568-576

[9] Yang J(1992)Components responsible for the undesirable taste of soybean seeds Biosci Biotechnol Biochem 56 99-103

[10] Brender JR(2009)Taste masking methods and techniques in oral pharmaceuticals: current perspectives J Pharm Res 2 1049-1054

[1] Lagerstrom MC(2008)Structural diversity of G protein-coupled receptors and significance for drug discovery Nat Rev Drug Discovery 7 339-357

[2] Schioth HB(2021)GPCRdb in 2021: integrating GPCR sequence, structure and function Nucleic Acids Res 49 D335-D343

[3] Kooistra AJ(2015)GLASS: a comprehensive database for experimentally validated GPCR-ligand associations Bioinformatics 31 3035-3042

[4] Mordalski S(2018)G protein-coupled receptors as targets for approved drugs: how many targets and how many drugs? Mol Pharmacol 93 251-258

[5] Pándy-Szekeres G(2019)BitterDB: taste ligands and receptors database in 2019 Nucleic Acids Res 47 D1179-D1185

[6] Esguerra M(2014)The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14 FASEB J 28 1181-1197

[7] Chan WK(2017)Bitterness prediction in-silico: a step towards better drugs Int J Pharm 536 526-529

[8] Zhang H(2021)Intense bitterness of molecules: machine learning for expediting drug discovery Comput Struct Biotechnol J 19 568-576

[9] Yang J(1992)Components responsible for the undesirable taste of soybean seeds Biosci Biotechnol Biochem 56 99-103

[10] Brender JR(2009)Taste masking methods and techniques in oral pharmaceuticals: current perspectives J Pharm Res 2 1049-1054