Regenerating functional heart tissue for myocardial repair

被引：0
作者：
Andre Alcon
Esra Cagavi Bozkulak
Yibing Qyang
机构：
[1] Yale University,Yale University School of Medicine
[2] Yale University,Section of Cardiovascular Medicine, Department of Internal Medicine, Yale Cardiovascular Research Center, Yale Stem Cell Center, Yale School of Medicine
来源：
Cellular and Molecular Life Sciences | 2012年 / 69卷
关键词：
Myocardial repair; Tissue engineering; Tissue regeneration; Heart tissue; Cardiac tissue; Heart repair; Heart regeneration;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Heart disease is one of the leading causes of death worldwide and the number of patients with the disease is likely to grow with the continual decline in health for most of the developed world. Heart transplantation is one of the only treatment options for heart failure due to an acute myocardial infarction, but limited donor supply and organ rejection limit its widespread use. Cellular cardiomyoplasty, or cellular implantation, combined with various tissue-engineering methods aims to regenerate functional heart tissue. This review highlights the numerous cell sources that have been used to regenerate the heart as well as cover the wide range of tissue-engineering strategies that have been devised to optimize the delivery of these cells. It will probably be a long time before an effective regenerative therapy can make a serious impact at the bedside.
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页码：2635 / 2656
页数：21
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