Mucosal Impedance: a New Approach to Diagnosing Gastroesophageal Reflux Disease and Eosinophilic Esophagitis

被引：19

作者：

Barrett C. ^{[1
]}

Choksi Y. ^{[1
]}

Vaezi M.F. ^{[1
]}

机构：

[1] Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt Medical Center, 1660 TVC, 1301 -22nd Ave. South, Nashville, 37232-5280, TN

来源：

Current Gastroenterology Reports | 2018年 / 20卷 / 7期

关键词：

Eosinophilic esophagitis; Gastroesophageal reflux disease; Mucosal impedance;

D O I：

10.1007/s11894-018-0639-4

中图分类号：

学科分类号：

摘要：

Purpose of Review: In this review, we discuss current diagnostic testing modalities for both gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) and then introduce mucosal impedance (MI), a novel technology that measures epithelial integrity in real time during endoscopy. We describe the advantages and disadvantages of MI as compared with traditional diagnostic testing. Recent Findings: We review studies that demonstrate that GERD and EoE have distinct MI patterns, and that physicians can accurately diagnose and distinguish the two during endoscopy with minimal time added to the procedure. We also review studies showing that MI has the capability to assess treatment response in both GERD and EoE and that it can be used to diagnose GERD in patients with extraesophageal reflux symptoms. Summary: Mucosal impedance testing is a major advancement in the diagnosis of GERD and EoE. Future studies are planned to assess whether MI can be used as a treatment endpoint in EoE and whether it can be used to predict response to anti-reflux surgery. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

引用

共 33 条

[1]

El-Serag H.B., Sweet S., Winchester C., Et al., Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review, Gut, 63, 6, pp. 871-880, (2014)

[2]

Sandler R.S., Everhart J.E., Donowitz M., Adams E., Cronin K., Goodman C., Gemmen E., Shah S., Avdic A., Rubin R., The burden of selected digestive diseases in the United States, Gastroenterology, 122, pp. 1500-1511, (2002)

[3]

Vaezi M.F., Sifrim D., Assessing old and new diagnostic tests for gastroesophageal reflux disease, Gastroenterology, 2017

[4]

Numans M.E., Lau J., de Wit N.J., Bonis P.A., Short-term treatment with proton-pump inhibitors as a test for gastroesophageal reflux disease: a meta-analysis of diagnostic test characteristics, Ann Intern Med, 140, pp. 518-527, (2004)

[5]

Madan K., Ahuja V., Gupta S.D., Et al., Impact of 24-h esophageal pH monitoring on the diagnosis of gastroesophageal reflux disease: defining the gold standard, J Gastroenterol Hepatol, 20, pp. 30-37, (2005)

[6]

Pandolfino J.E., Richter J.E., Ours T., Guardino J.M., Chapman J., Kahrilas P.J., Ambulatory esophageal pH monitoring using a wireless system, Am J Gastroenterol, 98, pp. 740-749, (2003)

[7]

Kahrilas P., Quigley E., American Gastroenterological Association medical position statement: guidelines on the use of esophageal pH recording, Gastroenterology, 110, (1996)

[8]

Hemmink G.J., Bredenoord A.J., Aanen M.C., Et al., Computer analysis of 24-h esophageal impedance signals, Scand J Gastroenterol, 46, pp. 271-276, (2011)

[9]

Shay S., Tutuian R., Sifrim D., Vela M., Wise J., Balaji N., Zhang X., Adhami T., Murray J., Peters J., Castell D., Twenty-four hour ambulatory simultaneous impedance and pH monitoring: a multicenter report of normal values from 60 healthy volunteers, Am J Gastroenterol, 99, pp. 1037-1043, (2004)

[10]

Sifrim D., Castell D., Dent J., Kahrilas P.J., Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, nonacid, and gas reflux, Gut, 53, pp. 1024-1031, (2004)

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