Patient-derived tumour xenografts as models for oncology drug development

被引：0
|
作者：
John J. Tentler
Aik Choon Tan
Colin D. Weekes
Antonio Jimeno
Stephen Leong
Todd M. Pitts
John J. Arcaroli
Wells A. Messersmith
S. Gail Eckhardt
机构：
[1] School of Medicine,Division of Medical Oncology, Department of Medicine
[2] University of Colorado,undefined
来源：
Nature Reviews Clinical Oncology | 2012年 / 9卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this Review, Tentler et al. present the opportunities and challenges of using patient-derived tumour xenograft models in oncology drug development, provide specific disease examples, and describe concepts regarding predictive biomarker development and future applications.
引用
收藏
页码：338 / 350
页数：12
相关论文
共 50 条
  • [41] Computational approach to discriminate human and mouse sequences in patient-derived tumour xenografts
    Maurizio Callari
    Ankita Sati Batra
    Rajbir Nath Batra
    Stephen-John Sammut
    Wendy Greenwood
    Harry Clifford
    Colin Hercus
    Suet-Feung Chin
    Alejandra Bruna
    Oscar M. Rueda
    Carlos Caldas
    BMC Genomics, 19
  • [42] Assessment of patient-derived tumour xenografts (PDXs) as a discovery tool for cancer epigenomics
    Paul Guilhamon
    Lee M Butcher
    Nadege Presneau
    Gareth A Wilson
    Andrew Feber
    Dirk S Paul
    Moritz Schütte
    Johannes Haybaeck
    Ulrich Keilholz
    Jens Hoffman
    Mark T Ross
    Adrienne M Flanagan
    Stephan Beck
    Genome Medicine, 6
  • [43] Decellularized patient-derived pancreatic ductal adenocarcinoma xenografts for tumour physicochemical characterization
    Garcia Gareta, Elena
    Gracia Costa, Carlos
    Enrique Guerrero, Pedro
    Alaman Diez, Pilar
    Rueda Flores, Ana
    Olivera Jurjo, Nerea
    Sancho, Patricia
    Angeles Perez, Maria
    Garcia Aznar, Jose Manuel
    TISSUE ENGINEERING PART A, 2023, 29 (13-14)
  • [44] Utilization of Patient-derived xenograft models in drug discovery and development research
    Yagishita, Shigehiro
    CANCER SCIENCE, 2024, 115 : 742 - 742
  • [45] Computational approach to discriminate human and mouse sequences in patient-derived tumour xenografts
    Callari, Maurizio
    Batra, Ankita Sati
    Batra, Rajbir Nath
    Sammut, Stephen-John
    Greenwood, Wendy
    Clifford, Harry
    Hercus, Colin
    Chin, Suet-Feung
    Bruna, Alejandra
    Rueda, Oscar M.
    Caldas, Carlos
    BMC GENOMICS, 2018, 19 : 19
  • [46] Patient-derived human tumour tissue xenografts in immunodeficient mice: a systematic review
    Ketao Jin
    Lisong Teng
    Yanping Shen
    Kuifeng He
    Zhenzhen Xu
    Guangliang Li
    Clinical and Translational Oncology, 2010, 12 : 473 - 480
  • [47] Patient-derived human tumour tissue xenografts in immunodeficient mice: a systematic review
    Jin, Ketao
    Teng, Lisong
    Shen, Yanping
    He, Kuifeng
    Xu, Zhenzhen
    Li, Guangliang
    CLINICAL & TRANSLATIONAL ONCOLOGY, 2010, 12 (07): : 473 - 480
  • [48] Utilizing Patient-Derived Xenografts to Model Precision Oncology for Biliary Tract Cancer
    Diperi, Timothy P.
    Evans, Kurt W.
    Scott, Stephen
    Zheng, Xiaofeng
    Varadarajan, Kaushik
    Kwong, Lawrence N.
    Kahle, Michael
    Cao, Hop S. Tran
    Tzeng, Ching-Wei
    Vu, Thuy
    Kim, Sunhee
    Su, Fei
    Raso, Maria Gabriela
    Rizvi, Yasmeen
    Zhao, Ming
    Wang, Huamin
    Lee, Sunyoung S.
    Yap, Timothy A.
    Rodon, Jordi
    Javle, Milind
    Meric-Bernstam, Funda
    CLINICAL CANCER RESEARCH, 2025, 31 (02) : 387 - 402
  • [49] PATIENT-DERIVED XENOGRAFTS MIRROR THE PROTEOMIC PROFILE OF HUMAN GLIOBLASTOMA: IMPLICATIONS FOR PERSONALIZED DRUG DEVELOPMENT
    Kwatra, Madan M.
    Brown, Kristine E.
    Chagoya, Gustavo
    Keir, Stephen T.
    Bigner, Darell D.
    Sampson, John H.
    NEURO-ONCOLOGY, 2014, 16
  • [50] Establishment of patient-derived xenografts (PDX) models for small cell lung (SCL) as a pre-clinical platform for drug development
    Broudy, T.
    Ricono, J.
    Mullins, C.
    Mirsaidi, C.
    Nair, P.
    EUROPEAN JOURNAL OF CANCER, 2014, 50 : 59 - 59
12345