Patient-derived tumour xenografts as models for oncology drug development

被引:0
|
作者
John J. Tentler
Aik Choon Tan
Colin D. Weekes
Antonio Jimeno
Stephen Leong
Todd M. Pitts
John J. Arcaroli
Wells A. Messersmith
S. Gail Eckhardt
机构
[1] School of Medicine,Division of Medical Oncology, Department of Medicine
[2] University of Colorado,undefined
来源
关键词
D O I
暂无
中图分类号
学科分类号
摘要
In this Review, Tentler et al. present the opportunities and challenges of using patient-derived tumour xenograft models in oncology drug development, provide specific disease examples, and describe concepts regarding predictive biomarker development and future applications.
引用
收藏
页码:338 / 350
页数:12
相关论文
共 50 条
  • [11] Orthotopic patient-derived xenografts are effective precision oncology models in predicting therapeutic response and acquired drug resistance
    Nakashima, Jonathan
    Sperry, Jantzen
    MOLECULAR CANCER THERAPEUTICS, 2021, 20 (12)
  • [12] Opportunities and challenges of patient-derived models in cancer research: patient-derived xenografts, patient-derived organoid and patient-derived cells
    Hou, Xiaoying
    Du, Cong
    Lu, Ligong
    Yuan, Shengtao
    Zhan, Meixiao
    You, Pengtao
    Du, Hongzhi
    WORLD JOURNAL OF SURGICAL ONCOLOGY, 2022, 20 (01)
  • [13] Opportunities and challenges of patient-derived models in cancer research: patient-derived xenografts, patient-derived organoid and patient-derived cells
    Xiaoying Hou
    Cong Du
    Ligong Lu
    Shengtao Yuan
    Meixiao Zhan
    Pengtao You
    Hongzhi Du
    World Journal of Surgical Oncology, 20
  • [14] PATIENT-DERIVED XENOGRAFTS FOR ACCELERATING PROSTATE CANCER DISCOVERY AND DRUG DEVELOPMENT
    Fazli, Ladan
    Lin, Dong
    Wang, Yuzhuo
    INTERNATIONAL JOURNAL OF UROLOGY, 2014, 21 : A45 - A45
  • [15] Patient-derived xenografts as preclinical neuroblastoma models
    Braekeveldt, Noemie
    Bexell, Daniel
    CELL AND TISSUE RESEARCH, 2018, 372 (02) : 233 - 243
  • [16] Patient-derived xenografts as preclinical neuroblastoma models
    Noémie Braekeveldt
    Daniel Bexell
    Cell and Tissue Research, 2018, 372 : 233 - 243
  • [17] PATIENT-DERIVED TUMOR XENOGRAFT MODELS: THE NEXT-GENERATION OF PRECLINICAL MODELS FOR ONCOLOGY DRUG DEVELOPMENT
    Eckhardt, S. G.
    Tan, A. C.
    Pitts, T.
    Leong, S.
    Arcaroli, J.
    Messersmith, W. A.
    Jimeno, A.
    Weekes, C. D.
    Tentler, J. J.
    ANNALS OF ONCOLOGY, 2012, 23 : 17 - 17
  • [18] Neuroblastoma patient-derived orthotopic xenografts: Clinically relevant models for drug testing
    Braekeveldt, Noemie
    Wigerup, Caroline
    Gisselsson, David
    Mohlin, Sofie
    Merselius, My
    Beckman, Siv
    Tadeo, Irene
    Berbegall, Anna P.
    Ora, Ingrid
    Navarro, Samuel
    Noguera, Rosa
    Pahlman, Sven
    Bexell, Daniel
    CANCER RESEARCH, 2016, 76
  • [19] Editorial: Patient-derived tumor models for drug development
    Sabaawy, Hatim E.
    Broggini, Massimo
    Gupta, Shiv K.
    FRONTIERS IN ONCOLOGY, 2023, 13
  • [20] Comparative mutational landscape analysis of patient-derived tumour xenografts
    Brait, Mariana
    Izumchenko, Evgeny
    Kagohara, Luciane T.
    Long, Samuel
    Wysocki, Piotr T.
    Faherty, Brian
    Fertig, Elana J.
    Khor, Tin Oo
    Bruckheimer, Elizabeth
    Baia, Gilson
    Ciznadija, Daniel
    Sloma, Ido
    Ben-Zvi, Ido
    Paz, Keren
    Sidransky, David
    BRITISH JOURNAL OF CANCER, 2017, 116 (04) : 515 - 523