Small RNA-based antimicrobial immunity

被引：0
作者：
Zhongxin Guo
Yang Li
Shou-Wei Ding
机构：
[1] Fujian Agriculture and Forestry University,Vector
[2] Fudan University,borne Virus Research Center, State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, College of Plant Protection
[3] University of California,State Key Laboratory of Genetic Engineering, Collaborative Innovation Centre of Genetics and Development, School of Life Sciences
来源：
Nature Reviews Immunology | 2019年 / 19卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, invertebrates and mammals, detailing the mechanisms for their production, amplification and activity. We also highlight the recent discovery of viral PIWI-interacting RNAs in animals and a new role for mobile host and pathogen small RNAs in plant defence against eukaryotic pathogens. In turn, viruses that infect plants, insects and mammals, as well as eukaryotic pathogens of plants, have evolved specific virulence proteins that suppress RNA interference (RNAi). Together, these advances suggest that an antimicrobial function of the RNAi pathway is conserved across eukaryotic kingdoms.
引用
收藏
页码：31 / 44
页数：13
相关论文
共 374 条
[41]  
Lee YS(2006)Genetic and functional diversification of small RNA pathways in plants Science 313 484-2622
[42]  
Segers GC(2007)An antagonistic function for Plant Cell 19 1625-9007
[43]  
Zhang X(2015) DCL2 in development and a new function for DCL4 in generating viral siRNAs Plant J. 81 5003-7540
[44]  
Deng F(2015)RNA interference-inducing hairpin RNAs in plants act through the viral defence pathway Plant Cell 27 2611-131
[45]  
Sun Q(2010)Hierarchical action and inhibition of plant dicer-like proteins in antiviral defense Plant Cell 22 8997-359
[46]  
Nuss DL(2010)Suppression of antiviral silencing by cucumber mosaic virus 2b protein in Proc. Natl Acad. Sci. USA 107 7529-3943
[47]  
Campo S(2011) is associated with drastically reduced accumulation of three classes of viral small interfering RNAs Plant Cell 23 105-1043
[48]  
Gilbert KB(2011)Differential contributions of plant Dicer-like proteins to antiviral defences against potato virus X in leaves and roots PLOS ONE 6 347-1047
[49]  
Carrington JC(2011)Functional and genetic analysis identify a role for Nucleic Acids Res. 39 3938-16090
[50]  
Sabin LR(2012) ARGONAUTE5 in antiviral RNA silencing PLOS Pathog. 8 1040-806
12345678910