Insulin-Like Growth Factor Binding Proteins 4 and 5 and Bone Mineral Density in Elderly Men and Women

被引：0

作者：

D. Karasik

C.J. Rosen

M.T. Hannan

K.E. Broe

B. Dawson-Hughes

D.R. Gagnon

P.W.F. Wilson

M. Visser

J.A. Langlois

S. Mohan

D.P. Kiel

机构：

[1] Hebrew Rehabilitation Center for Aged,

[2] Research and Training Institute and Harvard Medical School Division on Aging,undefined

[3] Boston,undefined

[4] MA,undefined

[5] USA,undefined

[6] Maine Center for Osteoporosis Research and Education,undefined

[7] St. Joseph Hospital,undefined

[8] Bangor,undefined

[9] ME,undefined

[10] USA,undefined

[11] Calcium and Bone Metabolism Laboratory,undefined

[12] Jean Mayer USDA Human Nutrition Research Center on Aging,undefined

[13] Tufts University,undefined

[14] Boston,undefined

[15] MA,undefined

[16] USA,undefined

[17] Department of Epidemiology and Biostatistics,undefined

[18] Boston University School of Public Health,undefined

[19] Boston,undefined

[20] MA,undefined

[21] USA,undefined

[22] Department of Medicine,undefined

[23] Boston University School of Medicine,undefined

[24] Boston,undefined

[25] MA,undefined

[26] USA,undefined

[27] EMGO Institute,undefined

[28] Vrije University Medical Center,undefined

[29] Amsterdam,undefined

[30] Netherlands,undefined

[31] Centers for Disease Control and Prevention,undefined

[32] National Center for Injury Prevention and Control,undefined

[33] Atlanta,undefined

[34] GA,undefined

[35] USA,undefined

[36] Musculoskeletal Disease Center,undefined

[37] Jerry L. Pettis Veterans Administration Medical Center,undefined

[38] Loma Linda,undefined

[39] CA,undefined

[40] USA,undefined

来源：

Calcified Tissue International | 2002年 / 71卷

关键词：

Bone Mineral Density; Lumbar Spine; Femoral Neck; Bone Mass; Proximal Femur;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Insulin-like growth factor-1 (IGF-I) plays a central role in the maintenance of bone mass. To test whether two major IGF-I binding proteins, IGFBP-4 and IGFBP-5, are related to bone mineral density (BMD), we studied a sample of the Framingham Offspring Cohort participants (99 men and 101 women, ages 60–87). Serum levels of IGF-I, IGFBP-4, and IGFBP-5 were measured by previously validated radioimmunoassays (CVs ~10%). BMDs of the proximal femur and lumbar spine were measured using a Lunar DPX-L densitometer. In males, but not females, IGF-I and IGFBP-5 were inversely associated with age (r = 0.34 and r = -?0.28, respectively; P <0.01), while IGFBP-4 levels were positively associated with age (P <0.01). Multivariate means for BMD (adjusted for age, body mass index, height, smoking, and in women, estrogen use) were computed across quartiles of IGFBP-4 and IGFBP-5 and IGFBP-4/IGFBP-5 ratio. In women, but not men, IGFBP-5 was positively associated with femoral neck BMD (P = 0.03), however, after statistical adjustment for IGF-I, this association was no longer significant. No other associations were observed for BMD at any other site. Further study is necessary for elucidation of the gender differences in the possible influence of IGF system components on bone mass.

引用

页码：323 / 328

页数：5