Prognostic and predictive biomarkers in renal cell carcinoma

被引：0
作者：
Michael M. Vickers
Daniel Y. C. Heng
机构：
[1] Tom Baker Cancer Centre,Department of Oncology
[2] University of Calgary,undefined
来源：
Targeted Oncology | 2010年 / 5卷
关键词：
Biomarkers; Renal cell carcinoma; von Hippel-Lindau (VHL); Vascular endothelial growth factor (VEGF); Hypoxia-inducible factor (HIF); Carbonic anhydrase IX (CAIX);
D O I：
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中图分类号：
学科分类号：
摘要：
With the recent advances in targeted therapies, biomarkers in renal cell carcinoma (RCC) continue to be developed. Historically, information regarding prognosis has come from clinicopathologic variables, however in recent years much research has focused on the molecular basis of renal cell cancer. The discovery of reliable biomarkers in RCC could have an important impact on diagnosis, prognosis, and prediction of therapeutic benefit. To date, most biomarker research has centered on byproducts of the von Hippel-Lindau (VHL) pathway including VHL mutations, vascular endothelial growth factor (ligands and receptors), hypoxia-inducible factor, and carbonic anhydrase IX. This review examines these potential biomarkers, biomarker prognostic models, and molecular expression profiles in the field of renal cell carcinoma.
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页码：85 / 94
页数：9
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