Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures

被引：0
作者：
Yu Yang
Jingjing Liu
Xiaoqi Sun
Liangzhu Feng
Wenwen Zhu
Zhuang Liu
Meiwan Chen
机构：
[1] University of Macau,State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences
[2] Soochow University,Institute of Functional Nano & Soft Materials Laboratory (FUNSOM)
来源：
Nano Research | 2016年 / 9卷
关键词：
near-infrared (NIR)-activable; drug delivery; aptamer; gold nanorods; single-walled carbon nanotubes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Stimuli-activated targeted delivery systems for highly accurate treatment of tumors have received considerable attention in recent years. Herein, we reveal a light-activable cancer-targeting strategy that uses a complementary DNA sequence to hybridize and mask sgc8 aptamers conjugated onto photothermal agents such as gold nanorods or single-walled carbon nanotubes (SWNTs). Upon exposure to near-infrared (NIR) laser, localized photothermal heating of the surface of those nano-agents results in dehybridization of the double-stranded DNA and uncaging of the aptamer sequence to allow specific cancer-cell targeting. Utilizing doxorubicin-loaded SWNTs as a model system, targeted drug delivery to cancer cells activated by NIR light was achieved. This work demonstrates the concept of NIR-activable tumor-targeting delivery systems with controllable cancer-cell binding to potentially enable highly specific and efficient cancer therapy.
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页码：139 / 148
页数：9
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