Catalyst-free tandem Michael addition-cyclization reactions in aqueous media for the synthesis of benzimidazo[1,2-a]pyrimidinone derivatives

被引：0
作者：
ChuanLi Ren
Yan Wang
Dong Wang
YongJun Chen
Li Liu
机构：
[1] Chinese Academy of Sciences,Beijing National Laboratory (BNLMS), CAS Key Laboratory for Molecular Recognition and Function
[2] Chinese Academy of Sciences,Institute of Chemistry
来源：
Science China Chemistry | 2010年 / 53卷
关键词：
queous media; Baylis-Hillman alcohol; 2-aminobenzimidazole; pesticidal activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The catalyst-free reactions of Baylis-Hillman alcohols (1a-i) with 2-aminobenzimidazole (2) in THF-H2O (1:4) were developed for the convenient and greener synthesis of benzimidazo[1,2-a]pyrimidinone derivatives (3a-i). The pesticidal activities of 3a-i were examined to investigate a new biological activity of the imidazo[1,2-a]pyrimidinone-type compounds.
引用
收藏
页码：1492 / 1496
页数：4
相关论文
共 96 条
  • [1] Rival Y.(1992)Synthesis and antibacterial activity of some imidazo[1,2-a]pyrimidine derivatives Chem Pharm Bull 40 1170-1176
  • [2] Grassy G.(1995)Synthesis and antiviral activity of 2 and 3-substituted imidazo[1,2-a] pyrimidine Nucleosides Nucleotides 14 551-554
  • [3] Michael G.(1997)Synthesis and benzodiazepine receptor binding of some imidazo-, pyrido[2,1-b]benzoxazoles and pyrimido[1,2-a] benzimidazoles Eur J Med Chem 32 83-89
  • [4] Gueiffieri A.(1988)Synthesis of 2-amino-5-hydroxy-4-pyrimidones and 5,6-biheteroaryls using Tetrahydron 44 3073-3078
  • [5] Blache Y.(2003)-nitrophenyl 3-bromo-2,2-diethoxypropionate (NPBDP) J. Heterocycl. Chem 40 1091-1096
  • [6] Chapat J.P.(2005)Synthesis of pyrimido[1,2-a]benzimidazol-4(10 Bioorg Med Chem Lett 15 5553-5557
  • [7] Elhakmaoui E.M.E.(2007))-one derivatives and evaluation of their interactions with DNA Chem Soc Rev 36 1581-1588
  • [8] Andrei G.(2003)A novel one-pot three-component reaction: Synthesis of triheterocyclic 4 Chem Rev 103 811-819
  • [9] Snoeck R.(2006)-pyrimido[2,1-b]benzazoles ring systems Chem Eur J 12 1312-1317
  • [10] De Clercq E.(2009)The Baylis-Hillman reaction: a novel source of attraction, opportunities, and challenges in synthetic chemistry Green Chem 11 1945-1947
12345678910