PON1 55 and 192 Gene Polymorphisms in Type 2 Diabetes Mellitus Patients in a Turkish Population

被引：33

作者：

Ergun, Mehmet Ali ^{[1
]}

Yurtcu, Erkan ^{[2
]}

Demirci, Huseyin ^{[3
]}

Ilhan, Mustafa N. ^{[4
]}

Barkar, Vahit ^{[5
]}

Yetkin, Ilhan ^{[6
]}

Menevse, Adnan ^{[5
]}

机构：

[1] Gazi Univ, Dept Med Genet, Fac Med, TR-06500 Ankara, Turkey

[2] Baskent Univ, Dept Med Biol, Fac Med, TR-06490 Ankara, Turkey

[3] Balikesir Ataturk Govt Hosp, Dept Endocrinol, Balikesir, Turkey

[4] Gazi Univ, Dept Publ Hlth, Fac Med, Besevler, Turkey

[5] Gazi Univ, Dept Med Biol & Genet, Fac Med, Besevler, Turkey

[6] Gazi Univ, Dept Endocrinol & Metab, Fac Med, Besevler, Turkey

来源：

BIOCHEMICAL GENETICS | 2011年 / 49卷 / 1-2期

关键词：

PON1; 55; 192; Diabetes mellitus; Polymorphism; HUMAN SERUM PARAOXONASE; DENSITY-LIPOPROTEIN LEVELS; ARYLESTERASE; RISK; VARIANT;

D O I：

10.1007/s10528-010-9376-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetes mellitus is a multifactorial metabolic disease, caused by the complete or relative absence of insulin hormone, which results in the deterioration of carbohydrate, protein, and lipid metabolism. The PON1 55 and 192 polymorphisms have been reported to be associated with type 2 diabetes and its complications. In this study, the involvement of the PON1 55 and 192 polymorphisms and paraoxonase enzyme activity in diabetic complications was assessed. The MM and QQ genotypes were the most frequent in complications of type 2 diabetes in both of the polymorphisms. PON enzyme activity was lower in the type 2 diabetes group with respect to the control group. Regarding both genotypes and enzyme activity, correlations were found between the PON1 55 and 192 genotypes and diabetic complications. This study thus helps to outline a genotype-phenotype relation for the PON1 gene in a Turkish population.

引用

页码：1 / 8

页数：8

共 23 条

[1] SERUM PARAOXONASE ACTIVITY, CONCENTRATION, AND PHENOTYPE DISTRIBUTION IN DIABETES-MELLITUS AND ITS RELATIONSHIP TO SERUM-LIPIDS AND LIPOPROTEINS [J].