Crystal and molecular structure of new tetrahydrobenzo[e]pyrano[4,3-b]pyridines

被引：0
作者：
E. V. Mironova
A. T. Gubaidullin
A. M. Murtazina
I. A. Litvinov
V. A. Mamedov
机构：
[1] Russian Academy of Sciences,Institute of Organic and Physical Chemistry, Kazan Scientific Center
来源：
Journal of Structural Chemistry | 2008年 / 49卷
关键词：
tetrahydrobenzo[; ]pyrano[4,3-; ]pyridines; crystal and molecular structure; X-ray single crystal diffraction;
D O I：
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摘要：
Three tetrahydrobenzo[e]pyrano[4,3-b]pyridines formed in a diethyl 2,4,6-trioxoheptanedicarboxylic ether-substituted salicylic aldehyde-ammonium acetate system were studied by single crystal X-ray diffraction. After the introduction of a methoxy group in the tricyclic system, the tetrahydropyridine and pyrane rings adopted the half-chair conformation, while in the unsubstituted compound, the tetrahydropyridine ring has a distorted boat conformation, and the pyrane ring has a C-envelope conformation. In the compounds, the N-H⋯O and O-H⋯O intermolecular hydrogen bonds give rise to the development of chain structures. In two of the three compounds examined, the hydrogen atoms at the chiral centers are in the trans-position, as in the structure of natural tetrahydrocannabinols.
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