Immunohistochemically proven cytomegalovirus gastrointestinal diseases in three patients with autoimmune diseases

被引：9

作者：

Fujita M. ^{[1
]}

Hatachi S. ^{[1
]}

Yagita M. ^{[1
]}

机构：

[1] Department of Medicine, Division of Clinical Immunology and Rheumatology, Kitano Hospital, Kita-ku, Osaka 530-8480

来源：

Clinical Rheumatology | 2008年 / 27卷 / 8期

关键词：

Autoimmune diseases; CMV antigenemia; Cytomegalovirus; Gastrointestinal disease;

D O I：

10.1007/s10067-008-0846-8

中图分类号：

学科分类号：

摘要：

Cytomegalovirus (CMV) disease is a serious infectious complication in compromised hosts. Therefore, there are several studies on the diagnosis and prophylactic/pre-emptive therapy of CMV diseases in patients with solid organ transplants, bone marrow transplants, hematopoietic stem cell transplants, and HIV diseases. However, in patients with autoimmune disease, there are only few studies on the diagnosis and prediction of CMV diseases. In the present article, we described three autoimmune cases that developed CMV gastrointestinal disease because of therapy-related immunosuppression. Although all three patients had a low-level CMV antigenemia without diarrhea or melena, CMV was detected in the gastrointestinal tract tissue. We concluded that CMV-antigenemia assay has a limited value in the diagnosis and prediction of CMV gastrointestinal disease in patients with autoimmune diseases, and that immunohistochemical confirmation of CMV tissue involvement should be recommended especially when the typical clinical gastrointestinal manifestations are lacking. © Clinical Rheumatology 2008.

引用

页码：1057 / 1059

页数：2

共 13 条

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