Mitophagy plays a "double-edged sword" role in the radiosensitivity of cancer cells

被引：6

作者：

Wang, Qian ^{[1
]}

Liu, Chengxin ^{[2
]}

机构：

[1] Lanzhou Univ, Sch Clin Med 1, Lanzhou 730030, Gansu, Peoples R China

[2] Shandong First Med Univ, Shandong Canc Hosp & Inst, Shandong Acad Med Sci, Jinan 250117, Shandong, Peoples R China

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2024年 / 150卷 / 01期

关键词：

Mitophagy; Radiosensitivity; Cancer; Ionizing radiation; MITOCHONDRIAL-DNA REPAIR; OXIDATIVE STRESS; SELECTIVE AUTOPHAGY; PROHIBITIN; DEATH; CARDIOLIPIN; APOPTOSIS; PROTEIN; ROS; IRRADIATION;

D O I：

10.1007/s00432-023-05515-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mitochondria are organelles with double-membrane structure of inner and outer membrane, which provides main energy support for cell growth and metabolism. Reactive oxygen species (ROS) mainly comes from mitochondrial and can cause irreversible damage to cells under oxidative stress. Thus, mitochondrial homeostasis is the basis for maintaining the normal physiological function of cells and mitophagy plays a pivotal role in the maintenance of mitochondrial homeostasis. At present, to enhance the sensitivity of cancer cells to radiotherapy and chemotherapy by regulating mitochondria has increasingly become a hot spot of cancer therapy. It is particularly important to study the effect of ionizing radiation (IR) on mitochondria and the role of mitophagy in the radiosensitivity of cancer cells. Most of the existing reviews have focused on mitophagy-related molecules or pathways and the impact of mitophagy on diseases. In this review, we mainly focus on discussing the relationship between mitophagy and radiosensitivity of cancer cells around mitochondria and IR.

引用

页数：12

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