Altered serum levels of insulin-like growth-factor binding proteins in breast cancer patients

被引：0
作者：
Eng-Hen Ng
Chen-Yang Ji
Puay-Hoon Tan
Valerie Lin
Khee-Chee Soo
Kok-Onn Lee
机构：
[1] National University of Singapore,From the Laboratory of Surgical Oncology and Metabolism, Department of Surgery
[2] National University of Singapore,Department of Pathology, Singapore General Hospital
[3] National University of Singapore,Department of Medicine
[4] Singapore General Hospital,Dept. of Surgery
来源：
Annals of Surgical Oncology | 1998年 / 5卷
关键词：
Insulin-like growth factor binding proteins; Breast cancer;
D O I：
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中图分类号：
学科分类号：
摘要：
Background: Insulin-like growth factor 1 (IGF-1) has mitogenic properties for breast cancer cell lines and has been proposed to be an important factor in breast carcinogenesis. We hypothesized that differences in IGF-1 or its binding proteins might increase susceptibility to breast cancer. This case-control study was designed to investigate whether patients with breast cancer have altered levels of either IGF-1 or its intermediary modulatory proteins, the IGF binding proteins (BP).
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页码：194 / 201
页数：7
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