MiRCancerdb: A database for correlation analysis between microRNA and gene expression in cancer

被引：21
作者：
Ahmed M. [1 ]
Nguyen H. [1 ]
Lai T. [1 ]
Kim D.R. [1 ]
机构：
[1] Department of Biochemistry and Convergence Medical Sciences, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju
来源：
BMC Research Notes | / 11卷 / 1期
基金：
新加坡国家研究基金会;
关键词：
Cancer; MicroRNA; miRCancerdb; TCGA;
D O I：
10.1186/s13104-018-3160-9
中图分类号：
学科分类号：
摘要：
Objectives: microRNAs regulate expression of target genes by specifically binding to their transcripts, subsequently leading to translational inhibition or mRNA degradation. Gene regulation by microRNAs has been implicated in a wide range of physiological and pathological conditions. Here, we leverage the use of public-access data and the available genomic annotations to pre-calculate the correlation of the expression of a large number of microRNAs with gene at the mRNA and protein level in the context of cancers. Results: Expression data of miRNAs, mRNAs and proteins in cancer patients from The Cancer Genome Atlas along with TargetScan miRNAs-target annotations were used to calculate the expression correlations between miRNAs and features (mRNAs/proteins) in a number of cancer studies. We then packed the output of this analysis into a database and made it available through an interactive web application. The miRCancerdb is an easy-to-use database to investigate the microRNAs-dependent regulation of target genes involved in development of cancer. © 2018 The Author(s).
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