A trans-synaptic nanocolumn aligns neurotransmitter release to receptors

被引：0
作者：
Ai-Hui Tang
Haiwen Chen
Tuo P. Li
Sarah R. Metzbower
Harold D. MacGillavry
Thomas A. Blanpied
机构：
[1] University of Maryland School of Medicine,Department of Physiology
[2] Program in Neuroscience,Department of Biology
[3] University of Maryland School of Medicine,undefined
[4] Medical Scientist Training Program,undefined
[5] University of Maryland School of Medicine,undefined
[6] Cell Biology,undefined
[7] Faculty of Science,undefined
[8] Utrecht University,undefined
来源：
Nature | 2016年 / 536卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Synaptic vesicle fusion, as evoked by action potentials, is confined to presynaptic protein nanoclusters, which are closely aligned with concentrated postsynaptic receptors and their scaffolding proteins—an organization termed a ‘nanocolumn’.
引用
收藏
页码：210 / 214
页数：4
相关论文
共 101 条
  • [1] Fromer M(2014) mutations in schizophrenia implicate synaptic networks Nature 506 179-184
  • [2] Volk L(2015)Glutamate synapses in human cognitive disorders Annu. Rev. Neurosci. 38 127-149
  • [3] Chiu S-L(2003)Independent sources of quantal variability at single glutamatergic synapses J. Neurosci. 23 3186-3195
  • [4] Sharma K(2013)Nanoscale scaffolding domains within the postsynaptic density concentrate synaptic AMPA receptors Neuron 78 615-622
  • [5] Huganir RL(2013)Super-resolution imaging reveals that AMPA receptors inside synapses are dynamically organized in nanodomains regulated by PSD95 J. Neurosci. 33 13204-13224
  • [6] Franks KM(2013)Local palmitoylation cycles define activity-regulated postsynaptic subdomains J. Cell Biol. 202 145-161
  • [7] Stevens CF(2012)The presynaptic active zone Neuron 75 11-25
  • [8] Sejnowski TJ(2008)Three-dimensional super-resolution imaging by stochastic optical reconstruction microscopy Science 319 810-813
  • [9] MacGillavry HD(2010)Superresolution imaging of chemical synapses in the brain Neuron 68 843-856
  • [10] Song Y(2012)Influence of synaptic vesicle position on release probability and exocytotic fusion mode Science 335 1362-1366
12345678910