Sensitive Analysis of Blonanserin, a Novel Antipsychotic Agent, in Human Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

被引：0
|
作者：
Tadashi Ogawa
Hideki Hattori
Rina Kaneko
Kenjiro Ito
Masayo Iwai
Yoko Mizutani
Tetsuya Arinobu
Akira Ishii
Osamu Suzuki
Hiroshi Seno
机构：
[1] Aichi Medical University School of Medicine,Department of Legal Medicine
[2] Nagoya University Graduate School of Medicine,Department of Legal Medicine and Bioethics
[3] Aichi Medical University School of Medicine,Department of Chemistry
[4] Hamamatsu University School of Medicine,Department of Legal Medicine
来源：
Analytical Sciences | 2010年 / 26卷
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摘要：
A rapid and sensitive method for analysis of blonanserin in human plasma by ultra-performance liquid chromatography– tandem mass spectrometry is presented. After pretreatment of a plasma sample by solid-phase extraction, blonanserin was analyzed by the system with a C18 column. This method gave satisfactory recovery rates, reproducibility, and good linearity of calibration curve in the range of 0.01 – 10.0 ng/mL for quality control samples spiked with blonanserin. The detection limit was as low as 1 pg/mL. This method seems very useful in forensic and clinical toxicology and pharmacokinetic studies.
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页码：1099 / 1102
页数：3
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