An oligosaccharide fraction from Korean mugwort herb suppresses death of the mouse thymocytes in culture by down-regulating the Fas death receptor gene

被引：0
作者：
Hye Kyung Chung
Eun Kyong Bae
Hee Jung Ji
Jung Suk Hwang
Dong Woon Park
Jung Eun Kim
Hwa Jin Jung
Hyun Ju Choi
Dong Seok Lee
Hyun Joo Youn
机构：
[1] Departments of Microbiology and School of Biotechnology & Biomedical Science,Department of Medical Technology
[2] Inje University,undefined
来源：
Biotechnology Letters | 2003年 / 25卷
关键词：
apoptosis; Fas; genomics; polysaccharide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Korean mugwort herb is a preparation of dried leaves from Artemisia species and has been used as a traditional medicine in Asia. An oligosaccharide fraction, AVF3, purified from the preparation promoted survival of the mouse thymocytes in culture. A mouse gene array study suggests that the AVF3 may modulate Fas/FasL dependent apoptotic cell death and thus has influence on the survival of the thymocytes in culture. RT-PCR analysis confirmed the down-regulation of the Fas gene by the AVF3 treatment, supporting that the AVF3 modulated thymocyte death by suppressing the Fas gene expression.
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页码：1549 / 1553
页数：4
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