Direct Relationship Between Uric Acid and C-Reactive Protein and Its Implication in the Chronic Kidney Disease

被引：0
作者：
Jaya Jeena
Sunita Manhas
Rajendra Prasad
Suvarna Prasad
Rajendra Gupta
机构：
[1] MMIMSR,Department of Biochemistry
[2] MMIMSR,Department of Medicine
来源：
Indian Journal of Clinical Biochemistry | 2022年 / 37卷
关键词：
Chronic kidney disease; Uric acid; C-reactive protein; Creatinine; Hypertension; Type 2 diabetes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Chronic Kidney disease (CKD) is a serious life threatening disease associated with morbidity and mortality in India. Hypothetical relationship between serum uric acid and C-Reactive protein (CRP) levels has been demonstrated in the pathophysiology of CKD. Fifty chronic kidney disease patients before dialysis and fifty controls were executed for measurement of serum uric acid and C-Reactive protein as well as other biochemical parameters analysis. Serum C-Reactive protein was measured by quantitative turbidimetric immunoassay. In this study, serum uric acid, creatinine, urea and C-Reactive protein levels were significant raised in CKD group to that of controls. Notably serum C-Reactive protein levels were significantly higher in the CKD patients associated with non-diabetic factors in comparison to diabetic associated CKD patients. A receiver operating characteristic curve (ROC) exhibited a strong association between uric acid and C-Reactive protein levels. A strong direct relationship between serum uric acid and C-Reactive protein in CKD patients are plausibly culprits in the progression of diseases.
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页码：365 / 369
页数：4
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[1]  
Johnson CA(2004)Clinical practice guidelines for chronic kidney disease in adults: part 1. Definition, disease stages, evaluation, treatment, and risk factors Am Family Phys 70 869-876
[2]  
Levey AS(2006)Chronic diseases now a leading cause of death in rural India—mortality data from the Andhra Pradesh Rural Health Initiative Int J Epidemiol 35 1522-1529
[3]  
Coresh J(2007)Epidemiology of type 2 diabetes: Indian scenario Indian J Med Res 125 217-230
[4]  
Levin A(2005)Definition and classification of chronic kidney disease: a position statement from kidney disease: Improving Global Outcomes (KDIGO) Kidney Int 67 2089-2100
[5]  
Eknoyan JG(2005)Molecular physiology of urate transport Physiology 20 125-133
[6]  
Lau J(2005)Molecular physiology of urate transport J Biomed Lab Sci 20 1-2
[7]  
Joshi R(2001)End-stage renal disease, atherosclerosis, and cardiovascular mortality: is C-reactive protein the missing link? Kidney Int 59 407-414
[8]  
Cardona M(2002)Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events New England J Med 347 1557-1565
[9]  
Iyengar S(2003)Relationship between C-reactive protein, albumin, and cardiovascular disease in patients with chronic kidney disease Am J Kidney Dis 42 44-52
[10]  
Sukumar A(2005)C-reactive protein and albumin as predictors of all-cause and cardiovascular mortality in chronic kidney disease Kidney Int 68 766-772
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