Recent Advances in Leukoaraiosis: White Matter Structural Integrity and Functional Outcomes after Acute Ischemic Stroke

被引：0
作者：
Mark R. Etherton
Ona Wu
Natalia S. Rost
机构：
[1] Harvard Medical School,Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology
[2] Massachusetts General Hospital,undefined
[3] J. Philip Kistler Stroke Research Center,undefined
[4] Massachusetts General Hospital,undefined
[5] Massachusetts General Hospital,undefined
来源：
Current Cardiology Reports | 2016年 / 18卷
关键词：
Leukoaraiosis; Ischemic stroke; Stroke recovery;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Leukoaraiosis, a radiographic marker of cerebral small vessel disease detected on T2-weighted brain magnetic resonance imaging (MRI) as white matter hyperintensity (WMH), is a key contributor to the risk and severity of acute cerebral ischemia. Prior investigations have emphasized the pathophysiology of WMH development and progression; however, more recently, an association between WMH burden and functional outcomes after stroke has emerged. There is growing evidence that WMH represents macroscopic injury to the white matter and that the extent of WMH burden on MRI influences functional recovery in multiple domains following acute ischemic stroke (AIS). In this review, we discuss the current understanding of WMH pathogenesis and its impact on AIS and functional recovery.
引用
收藏
相关论文
共 475 条
[1]  
Wong TY(2002)Study AIARiC: cerebral white matter lesions, retinopathy, and incident clinical stroke JAMA 288 67-74
[2]  
Klein R(2006)Silent brain infarction and subcortical white matter lesions increase the risk of stroke and mortality: a prospective cohort study J Stroke Cerebrovasc Dis 15 57-63
[3]  
Sharrett AR(2009)Cerebral white matter lesions are associated with the risk of stroke but not with other vascular events: the 3-City Dijon Study Stroke 40 2327-31
[4]  
Couper DJ(2010)Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study Stroke 41 600-6
[5]  
Klein BE(2010)The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis BMJ 341 c3666-9
[6]  
Liao DP(2012)Risk of intraparenchymal hemorrhage with magnetic resonance imaging-defined leukoaraiosis and brain infarcts Ann Neurol 71 552-12
[7]  
Bokura H(2004)White matter lesions, cognition, and recurrent hemorrhage in lobar intracerebral hemorrhage Neurology 63 1606-22
[8]  
Kobayashi S(2003)Risk factors for dementia in the Cardiovascular Health Cognition Study Neuroepidemiology 22 13-4
[9]  
Yamaguchi S(2004)Cerebral white matter lesions and the risk of dementia Arch Neurol 61 1531-6
[10]  
Iijima K(2009)Brain tissue volumes and small vessel disease in relation to the risk of mortality Neurobiol Aging 30 450-5
12345678910