Allergic reaction to hyaluronidase after retrobulbar anaesthesia: A case series and review

被引：25

作者：

Delaere L. ^{[1
]}

Zeyen T. ^{[1
]}

Foets B. ^{[1
]}

Van Calster J. ^{[1
]}

Stalmans I. ^{[1
]}

机构：

[1] Department of Ophthalmology, University Hospitals Leuven, Campus St Raphaël, Leuven 3000

来源：

International Ophthalmology | 2009年 / 29卷 / 6期

关键词：

Allergy; Hyaluronidase; Retrobulbar anaesthesia;

D O I：

10.1007/s10792-008-9258-7

中图分类号：

学科分类号：

摘要：

Background The enzyme hyaluronidase (HA) is an adjunctive in retrobulbar anaesthesia (RA) that is used during ophthalmic surgery to improve the efficacy and speed of nerve blocks. Although uncommon, HA has been shown to be a potential cause of allergic responses. Case reports We describe three patients who experienced an allergic reaction to HA following ocular surgery in our department and provide an extensive overview of the literature on HA in RA. Conclusions Although rare and mostly benign, allergy to HA should be included in the differential diagnosis when chemosis, proptosis and restriction of eye movements occur after parabulbar or retrobulbar anaesthesia. The authors feel that the beneficial effect of HA in small volumes of RA warrants its use despite this potential complication. © 2008 Springer Science+Business Media B.V.

引用

页码：521 / 528

页数：7

共 29 条

[1]

Rowley S.A., Hale J.E., Finlay R.D., Sub-Tenon's local anaesthesia: The effect of hyaluronidase, British Journal of Ophthalmology, 84, 4, pp. 435-436, (2000)

[2]

Alwitry A., Chaudhary S., Gopee K., Butler T.K.H., Holden R., Effect of hyaluronidase on ocular motility in sub-Tenon's anesthesia: Randomized controlled trial, Journal of Cataract and Refractive Surgery, 28, 8, pp. 1420-1423, (2002)

[3]

Afify A.M., Stern M., Guntenhoner M., Stern R., Purification and characterization of human serum hyaluronidase, Arch Biochem Biophys, 305, pp. 434-441, (1993)

[4]

Kempeneers R., Dralands L., Ceuppens J., Hyaluronidase induced orbital pseudotumor as a complication of retrobulbar anesthesia, Bull Soc Belge Ophtalmol, 243, pp. 159-166, (1992)

[5]

Quhill F., Bowling B., Packard R.B., Hyaluronidase allergy after peribulbar anesthesia with orbital inflammation, Journal of Cataract and Refractive Surgery, 30, 4, pp. 916-917, (2004)

[6]

Eberhart A.H., Weiler C.R., Erie J.C., Angioedema related to the use of hyaluronidase in cataract surgery, American Journal of Ophthalmology, 138, 1, pp. 142-143, (2004)

[7]

Youssef Z., Pennefather P.M., Watts M.T., Varma D., Metcalfe T.E., Orbital cellulitis vs allergic reaction to hyaluronidase as the cause of periorbital oedema (multiple letters) [3], Eye, 19, 6, pp. 691-692, (2005)

[8]

Ahluwalia H.S., Lukaris A., Lane C.M., Delayed allergic reaction to hyaluronidase: A rare sequel to cataract surgery [12], Eye, 17, 2, pp. 263-266, (2003)

[9]

Musa F., Srinivasan S., King C.M., Kamal A., Raised intraocular pressure and orbital inflammation: A rare IgE-mediated allergic reaction to sub-Tenon's hyaluronidase, Journal of Cataract and Refractive Surgery, 32, 1, pp. 177-178, (2006)

[10]

Finch T.M., Prais L., Foulds I.S., Occupational allergic contact dermatitis from quaternium-15 in an electroencephalography skin preparation gel, Contact Dermatitis, 44, 1, pp. 44-45, (2001)

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