Successful unrelated donor cord blood transplantation for chronic granulomatous disease

被引：0
作者：
Tang-Her Jaing
Wen I Lee
Po-Jen Cheng
Shih-Hsiang Chen
Jing-Long Huang
Yung-Kuei Soong
机构：
[1] Chang Gung Children’s Hospital,Division of Hematology and Oncology, Department of Pediatrics
[2] Chang Gung University,Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics
[3] Chang Gung Children’s Hospital,Lin
[4] Chang Gung University,Kou Medical Center, Department of Obstetrics and Gynecology
[5] Chang Gung Memorial Hospital,undefined
[6] Chang Gung University,undefined
来源：
International Journal of Hematology | 2010年 / 91卷
关键词：
Chronic granulomatous disease; Unrelated cord blood transplantation; Young infant;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This report exemplified a success of unrelated donor cord blood transplantation (CBT) in a 4-month-old boy with chronic granulomatous disease (CGD). Following Bu14/Cy200/ATG conditioning, the patient received an HLA 2-locus-mismatched cord blood unit, and the total number of infused nucleated cells was 11.52 × 107/kg. Neutrophil engraftment was achieved on day +13, and a platelet count greater than 20 × 109/L was achieved on day +50. The neutrophil oxidative burst was 100% normal with full donor lymphocyte reconstitution at 8 months post-transplant. This case highlights that unrelated donor CBT for CGD is potentially safe and feasible, even in early infancy, when an appropriately matched related or unrelated donor is unavailable.
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页码：670 / 672
页数：2
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