Quantifying Protein Function Specificity in the Gene Ontology

被引：0
作者：
Brenton Louie
Silas Bergen
Roger Higdon
Eugene Kolker
机构：
[1] Seattle Children’s Research Institute,Bioinformatics and High
[2] Seattle Children’s Hospital,throughput Analysis Laboratory
[3] University of Washington School of Public Health,Predictive Analytics
[4] University of Washington School of Medicine,Department of Biostatistics
来源：
Standards in Genomic Sciences | 2010年 / 2卷
关键词：
protein annotation; protein function; function specificity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Quantitative or numerical metrics of protein function specificity made possible by the Gene Ontology are useful in that they enable development of distance or similarity measures between protein functions. Here we describe how to calculate four measures of function specificity for GO terms: 1) number of ancestor terms; 2) number of offspring terms; 3) proportion of terms; and 4) Information Content (IC). We discuss the relationship between the metrics and the strengths and weaknesses of each.
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页码：238 / 244
页数：6
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