A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis

[1] Prentki M(1996)Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45 273-283

[2] Corkey BE(1964)Hormone-sensitive lipase and monoglyceride lipase activities in adipose tissue J Biol Chem 239 401-409

[3] Vaughan M(2004)Hormone-sensitive lipase—new roles for an old enzyme Biochem J 379 11-22

[4] Berger JE(2000)Molecular mechanisms regulating hormone-sensitive lipase and lipolysis Annu Rev Nutr 20 365-393

[5] Steinberg D(1999)Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells Diabetes 48 228-232

[6] Yeaman SJ(1989)A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells J Biol Chem 264 21608-21612

[7] Holm C(2000)Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells) J Biol Chem 275 9363-9368

[8] Osterlund T(2005)Regulation of lipolytic activity by long-chain acyl-coenzyme A in islets and adipocytes Am J Physiol Endocrinol Metab 289 E1085-E1092

[9] Laurell H(2004)Function of hormone-sensitive lipase in diacylglycerol-protein kinase C pathway Diabetes Res Clin Pract 65 209-215

[10] Contreras JA(2000)Long-chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated insulin secretion in clonal beta-cells Endocrinology 141 1989-1998

[1] Prentki M(1996)Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45 273-283

[2] Corkey BE(1964)Hormone-sensitive lipase and monoglyceride lipase activities in adipose tissue J Biol Chem 239 401-409

[3] Vaughan M(2004)Hormone-sensitive lipase—new roles for an old enzyme Biochem J 379 11-22

[4] Berger JE(2000)Molecular mechanisms regulating hormone-sensitive lipase and lipolysis Annu Rev Nutr 20 365-393

[5] Steinberg D(1999)Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells Diabetes 48 228-232

[6] Yeaman SJ(1989)A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells J Biol Chem 264 21608-21612

[7] Holm C(2000)Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells) J Biol Chem 275 9363-9368

[8] Osterlund T(2005)Regulation of lipolytic activity by long-chain acyl-coenzyme A in islets and adipocytes Am J Physiol Endocrinol Metab 289 E1085-E1092

[9] Laurell H(2004)Function of hormone-sensitive lipase in diacylglycerol-protein kinase C pathway Diabetes Res Clin Pract 65 209-215

[10] Contreras JA(2000)Long-chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated insulin secretion in clonal beta-cells Endocrinology 141 1989-1998