Early elevated alkaline phosphatase as a surrogate biomarker of ongoing metabolic bone disease of prematurity

被引：0
作者：
Emmanuelle Motte-Signoret
Marwa Jlassi
Ludivine Lecoq
Pierre-Yves Wachter
Amélie Durandy
Pascal Boileau
机构：
[1] Poissy St Germain Hospital,INRAE, BREED
[2] Neonatal Intensive Care Unit,undefined
[3] CHI Poissy-St Germain,undefined
[4] Université Paris-Saclay,undefined
[5] UVSQ,undefined
[6] Université Paris-Saclay,undefined
[7] INSERM,undefined
来源：
European Journal of Pediatrics | 2023年 / 182卷
关键词：
Alkaline phosphatase; Metabolic bone disease; Surrogate biomarker; Prematurity ;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Very low birth weight (VLBW) neonates present a high risk of metabolic bone disease (MBD). Our main objective was to determine the easiest way to make an early diagnosis of this disease by identifying surrogate biomarkers before any radiological signs occurred. We conducted in our NICU a 6-month observational prospective study, with inclusion of all singleton VLBW neonates. We collected clinical and biological data, and nutritional intakes during hospitalization. We defined biological MBD (bMBD) as alkaline phosphatase (ALP) levels superior to 600 UI/L at day of life 30 (DOL30) and performed a case–control analysis. Nine out of 30 patients (30%) exhibited bMBD. All have extremely low birth weight and were significantly younger in gestational age (GA) and smaller at birth. There was no statistically significant difference in nutritional intake between bMBD and control groups. In the bMBD group, phosphatemia was lower since DOL3. ALP was already significantly higher at DOL15, and way beyond normal range.
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页码：1829 / 1837
页数：8
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