Reversal of diabetic retinopathy in streptozotocin induced diabetic rats using traditional Indian anti-diabetic plant, Azadirachta indica (L.)

被引：15

作者：

Ali Hussain H.E.M. ^{[1
]}

机构：

[1] C/o Dr. Paul Ratnasamy, National Chemical Laboratory

来源：

Indian Journal of Clinical Biochemistry | 2002年 / 17卷 / 2期

关键词：

Azadirachta indica; Diabetes mellitus; Diabetic retinopathy; Hypoglycemic effect; Hypolipidemic effect;

D O I：

10.1007/BF02867983

中图分类号：

学科分类号：

摘要：

This study was carried out to investigate the effect of oral feeding of water extract of fresh leaves of Azadirachta indica (Fam: Meliaceae) in streptozotocin induced diabetes and its associated retinopathy in rats. Treatment of the diabetic rats with aqueous extract of leaves of A. indica at a dose of 250 mg/kg body weight for 16 weeks resulted in gradual but significant fall in blood glucose and improvement in serum total, LDL and HDL cholesterol and triacylglycerol which increased in diabetic rats. It also showed improvement in body weight and reversed retinopathy.

引用

页码：115 / 123

页数：8

共 8 条

[1]

Shukla R., Sharma S.B., Puri D., Prabhu K.M., Murthy P.S., Medicinal Plants for treatment of diabetes mellitus, Ind. J. Clin. Biochem, 15, SUPPL., pp. 169-177, (2000)

[2]

Satyarati G.V., Raina M.K., Sharma M., Medicinal plants of India, Indian Council of Medical Research, pp. 65-68, (1976)

[3]

Ghattopadhyay R.R., Possible mechanism of antihyperglycemic effect of Azadirachta indica leaf extract part 1V, Gen. Pharmacal Col. Letrs, 27, 3, pp. 431-434, (1996)

[4]

Sonia B., Srinivasan B.P., Investigations in to the Anti-diabetic activity of Azadirachta indica, Indian Journal of Pharmacology, 31, pp. 138-141, (1999)

[5]

Chattopadhyay R.R., Chattopadhyay R.N., Maitra S.K., Effect of A. indica on hepatic glycogen in rats. lnd, J. Pharmacol, 25, pp. 174-175

[6]

Hussain H.E.M.A., Jamil K., Rao M., Hypoglycemic, hypolipidemic and antioxidant properties of Tulsi (Ocimum sanctum Linn) on strteptozotocin induced diabetes rats.lnd, J. Clin. Biochem, 16, 2, pp. 190-194, (2001)

[7]

Hussain H.E.M.A., Jamil K., Rao M., Preliminary studies on the hypoglycemic effect of Abroma augusta in alloxan diabetic rats. lnd, J.Clin.Biochem, 16, 1, pp. 77-80, (2001)

[8]

Shukla R., Anand K., Prabhu K.M., Murthy P.S., Hypolipidemic effect of water extract of Ficus bengalensis in alloxan induced diabetes mellitus in rabbits, lnd, J. Clin. Biochem, 14, 2, pp. 122-124, (1995)

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